Publications by authors named "Sydney A Leibel"
Background: Human milk is unquestionably beneficial for preterm infants. We investigated how the transition from tube to oral/breastfeeding impacts the preterm infants' oral and gut microbiome and metabolome.
Methods: We analyzed stool, saliva, and milk samples collected from a cohort of preterm infants enrolled in the MAP Study, a prospective observational trial.
Article Synopsis
- There is limited research on the allergen content in milk feeds for preterm infants, highlighting a gap in understanding their potential impact on allergies.
- Initial tests were conducted using mass spectrometry on human milk samples, revealing a significant presence of nonhuman proteins from various species, including potential allergens.
- The study suggests that the composition of milk feeds could influence the risk of developing atopic diseases in preterm infants, prompting further investigation into the role of allergens and proteases in their immune response.
Preterm infants are at a greater risk for the development of asthma and atopic disease, which can lead to lifelong negative health consequences. This may be due, in part, to alterations that occur in the gut microbiome and metabolome during their stay in the Neonatal Intensive Care Unit (NICU). To explore the differential roles of family history (i.
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