Publications by authors named "Syaripah Sundari"
Orf239342 from the mushroom Agaricus bisporus is a mannose binding protein.
Biochem Biophys Res Commun
July 2019
Article Synopsis
- A newly identified protein from mushrooms, called orf239342, can inhibit the growth of MCF-7 breast cancer cells by specifically binding to sugars on the cell's surface.
- Through experiments, it was found that orf239342 binds most effectively to mannose, and the presence of mannose can reduce the protein's ability to inhibit cancer cell growth.
- This research not only helps categorize orf239342 in relation to its function and association with tyrosinase, but it also opens up potential applications for this protein in breast cancer treatment, leading to its new designation as Agaricus bisporus mannose binding-protein (AbMb).
The light subunit of mushroom Agaricus bisporus tyrosinase (LSMT) is a protein of unknown function that was discovered serendipitously during the elucidation of the crystal structure of the enzyme. The protein is non-immunogenic and can penetrate the intestinal epithelial cell barrier, and thus, similar to its structural homologue HA-33 from Clostridium botulinum, may be potentially absorbable by the intestine. LSMT also shares high structural homology with the ricin-B-like lectin from the mushroom Clitocybe nebularis (CNL), which has been shown to display biological activity against leukemic cancer cells and dendritic cells.
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