Mitigating the impact of image processing variations on tumour [F]-FDG-PET radiomic feature robustness.

Radiomics analysis of [F]-fluorodeoxyglucose ([F]-FDG) PET images could be leveraged for personalised cancer medicine. However, the inherent sensitivity of radiomic features to intensity discretisation and voxel interpolation complicates its clinical translation. In this work, we evaluated the robustness of tumour [F]-FDG-PET radiomic features to 174 different variations in intensity resolution or voxel size, and determined whether implementing parameter range conditions or dependency corrections could improve their robustness.

Radiomic Signatures Associated with CD8 Tumour-Infiltrating Lymphocytes: A Systematic Review and Quality Assessment Study.

The tumour immune microenvironment influences the efficacy of immune checkpoint inhibitors. Within this microenvironment are CD8-expressing tumour-infiltrating lymphocytes (CD8 TILs), which are an important mediator and marker of anti-tumour response. In practice, the assessment of CD8 TILs via tissue sampling involves logistical challenges.

Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review.

Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological hypoxia (<0.1% O2) cells become up to three times more resistant to radiation.