Primary cervical lymphoma: the role of cervical cytology.

Two cases of primary malignant lymphoma of the uterine cervix are reported. Both were confirmed by histology as high grade B cell lymphomas. In one case, the diagnosis was made on a second colposcopic biopsy after an initial cervical smear and colposcopic biopsy were negative.

Squamous intraepithelial neoplasia in an ovarian cyst, cervical intraepithelial neoplasia, and human papillomavirus.

A case of squamous intraepithelial neoplasia in an ovarian cyst in association with cervical intraepithelial neoplasia (CIN) III is described. In view of the association of human papillomavirus (HPV) and CIN, the possibility that HPV infection could be associated with similar changes in the ovary was postulated. The HPV genome was shown in formalin-fixed tissue of the cervical lesion by nonisotopic in situ hybridization (NISH) and by the polymerase chain reaction (PCR).

Malignant histiocytosis of the intestine: report of three cases with immunological and cytochemical analysis.

Tumour cells from three cases of malignant histiocytosis of the intestine (MHI) have been studied immunologically and cytochemically. The cells did not form E rosettes and showed weak Fc gamma surface receptors. They contained non-specific esterase and acid phosphatase in diffuse granular distribution.

Malignant interstitial cell tumor of the testis.

The light microscopic and ultrastructural characteristics of a hormonally active Leydig cell tumor are described. Evidence is adduced that strongly suggests that the Leydig cell tumor was malignant and that functioning metastases were present.

A new regimen for the treatment of vaginal carcinoma in situ using 5-fluorouracil. Case report.

A patient with vaginal carcinoma in situ was treated with 5-fluorouracil in a less intensive regimen that previously recorded. This appeared to be effective and did not cause serious vaginal discomfort or dyspareunia.

Angiolymphoid hyperplasia with eosinophilia involving skeletal muscle.

A vascular tumour involving the trapezius muscle is described. In addition to proliferating blood vessels with perithelial cuffing, there was a distinctive stroma of lymphoid aggregates, plasmacytoid cells, some mast cells and large numbers of eosinophils, many with a perivascular distribution. This solely intramuscular lesion was considered to be an example of angiolymphoid hyperplasia with eosinophilia.

Abortion associated with intrauterine infection by candida albicans. Case report.

A 27-year-old patient who became pregnant whilst fitted with an intrauterine contraceptive device developed an intrauterine Candida albicans infection and aborted. The diagnostic (and other inconspicuous) features of C. Albicans infection in the fetus are described.

Malignant histiocytosis of the intestine.

Four cases of malignant histiocytosis of the intestine (MHI) are described in detail, with emphasis on the clinical features and laboratory findings that may lead to a diagnosis. MHI is a rapidly progressive, usually fatal condition, which may occur in a setting of adult celiac disease or apparently spontaneously; all patients, however, have villous atrophy and crypt hyperplasia of the jejunum. Characteristic symptoms are malaise, weight loss, abdominal pain, and diarrhea followed, after a period of weeks or months, by acute small intestinal obstruction, perforation, or bleeding.

Mixed mesenchymal sarcoma of the broad ligament: case report.

A 55-year-old patient who presented with a pelvic mass was found to have a mixed mesenchymal sarcoma of the broad ligament. The histogenesis and diagnostic criteria of this rare tumour are discussed.

Intestinal ischaemia associated with ileal carcinoid tumours.

A case of intestinal infarction due to multiple ileal carcinoid tumours is presented in which abdominal pain due to intestinal ischaemia was the first manifestation of the underlying tumour. It is postulated that intestinal ischaemia may be of more importance in the production of abdominal pain by carcinoid tumours than has been generally accepted, and that it is the result of functional and structural changes in the around the mesenteric blood vessels, caused by substances secreted by the carcinoid tumour.

A fundal cyst of the gallbladder: An unusual abdominal mass.

A female, aged 80 years, presenting with a large abdominal mass causing distension and right-sided hydronephrosis, is presented. The mass proved to be a unilocular cyst attached to the fundus of a thick-walled gallbladder. Histological examination demonstrated invasive adenocarcinoma in the gallbladder.

Disseminated intravascular coagulation as a consequence of cerebral damage.

Three cases with intracranial lesions developed evidence of disseminated intravascular coagulation which was confirmed at necropsy. The factors engendering this state, including release of potent thromboplastin from neural tissue are discussed and the danger of this intermediary mechanism of disease increasing the mortality of intracranial disease is demonstrated. Careful haematological investigation of all patients with intracranial disease is therefore advised, especially if they manifest evidence of a bleeding tendency.