Genetic analysis of cleft lip and cleft palate in southern Poland. II. Complex segregation analysis.

A complex segregation analysis based on the maximum likelihood method was applied on a sample of 329 families with CP and 687 families with CL +/- P. The results for CP malformations were equivocal, since the authors were unable to distinguish between the hypothesis of recessive inheritance with complete penetrance (chi 2 = 19.60) and that of multifactorial inheritance (chi 2 = 20.

Genetic analysis of cleft lip and cleft palate in southern Poland. I. Empiric and relative recurrence risks.

The study covered 1009 families with CL +/- P and 490 families with CP coming from the region of southern Poland wherein the incidence is 1.3/1000 for CL +/- P and 0.51/1000 for CP.