Publications by authors named "Swetamudra Pattnaik"

Homeotic transformation of tail to hindlimbs in anuran tadpoles is a manifestation of the reprogramming of positional information in the event of tail regeneration. Such discovery of homeosis is of particular interest considering its occurrence in a vertebrate under the influence of a morphogen which represents a self-organizing system in the context of developmental and regenerative studies. This article reviews homeotic transformation of tail to hindlimbs including pelvic girdles induced by retinoic acid (RA) /vitamin A palmitate during tail regeneration under the scope of self-organization and the role of blastema as an organizer.

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RNA helicase DDX5 is a host restriction factor for hepatitis B virus (HBV) biosynthesis. Mass spectrometry (LC-MS/MS) identified significant DDX5-interacting partners, including interferon-inducible protein 16 (IFI16) and RBBP4/7, an auxiliary subunit of polycomb repressive complex 2 (PRC2). DDX5 co-eluted with IFI16, RBBP4/7, and core PRC2 subunits in size exclusion chromatography fractions derived from native nuclear extracts.

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Patients in the intensive care unit (ICU) may need bedside endoscopy for gastrointestinal (GI) emergencies. Conducting endoscopy in the ICU for critically ill patients needs special consideration. This mini review focuses on indications for bedside endoscopes, including GI bleeding, volvulus, and bowel obstruction.

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Photodynamic Therapy (PDT) offers a minimally invasive approach for treating various health conditions, employing a photosensitizer (PS) and specific light. Recent enhancements make PDT outpatient-friendly and less discomforting. Effectiveness hinges on selecting the appropriate PS.

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Background: The foremost concern and challenge in managing drug-resistant tuberculosis is ensuring a high health-related quality of life (HRQoL). The effectiveness of pre-extensively drug-resistant (Pre-XDR) tuberculosis management hinges on patients adhering to therapy, a crucial factor in averting the development of drug-resistant strains, ultimately enhancing HRQoL.

Methodology: This analytical longitudinal study spanned two years at a teaching hospital and involved collaboration between the Departments of Pharmacology and Pulmonary Medicine.

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The maxillary anteriors play the most prominent role in an individual's aesthetics, speech, and majorly psychology. The impaction of maxillary anterior teeth can be a challenging orthodontic problem that can be managed by interceptive orthodontics in early mixed dentition. In this particular case report, interceptive orthodontics alone may not bring desirable results because two problems need to be dealt simultaneously, namely, intraosseous crowding and midline shift due to impaction on the affected quadrant.

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In recent years, Internet Addiction Disorder (IAD) has become a major mental health concern among adolescents, with detrimental effects on social relationships, academic performance, and emotional well-being. The focus of mindfulness-based interventions (MBIs) on improving self-awareness, emotional regulation, and cognitive flexibility has drawn interest in MBIs as possible therapeutic approaches for treating IAD. The purpose of this narrative review is to investigate how mindfulness interventions affect teenagers who are experiencing IAD.

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Present study reports analgesic and anti-inflammatory potential of (L.) leaf oil loaded lipid nanocarrier (BLNs)-embedded bigel. BLNs were developed by solvent evaporation technique and were characterised by FESEM, Cryo-TEM, mean diameter, zeta potential, loading efficiency, etc.

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Background: Differentiating the various liver tumors is pivotal due to distinct treatments and prognoses. Sometimes, it is difficult to accurately differentiate hepatocellular carcinoma (HCC) from other hepatic neoplasms non-invasively because of overlap in the triple-phase contrast-enhanced computed tomography (CECT) features, contraindication of an invasive biopsy, particularly in multifocal lesions with cirrhosis or ascites or when an MRI is unavailable or not feasible.

Objectives: To assess the utility of CT perfusion (CTP) parameters in differentiating HCC from other hepatic neoplasms.

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Article Synopsis
  • - The study investigates the effect of 4-butylcyclohexane carboxylic acid (4-BCCA), a potential epilepsy treatment, in comparison to standard antiseizure medications in a rat model of status epilepticus.
  • - 4-BCCA demonstrated effective seizure control and neuroprotection, with the best results observed when combined with the medication perampanel, showing improved memory retention and neuronal viability.
  • - The findings suggest that 4-BCCA could be a promising therapeutic option for managing seizures and reducing neurodegeneration in epilepsy, warranting further investigation.
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  • Needle stick injuries (NSIs) pose serious health risks for healthcare workers, exposing them to blood-borne infections like HIV, HBV, and HCV; this study analyzed NSI cases over four years from a hospital in India.
  • The study recorded 115 NSI cases from 2019 to 2022, with a higher incidence among younger healthcare workers, especially nurses in the initial years, while housekeeping staff were more affected in later years; most injuries occurred during morning shifts and in the inpatient department.
  • Post-exposure prophylaxis was administered to a subset of affected workers, with a negative HIV serology status for all tested, although some cases showed positive for HBV and HCV.
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Left-sided portal hypertension (LPH) refers to increased splenic venous pressure caused by splenic vein stenosis or occlusion. Pancreatitis is the leading cause of LPH. Typically, LPH remains asymptomatic, but it can lead to life-threatening hemorrhage from ruptured fundal varices in about 10% of patients.

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Hexavalent chromium (Cr(vi)) is a prominent carcinogen. In environmental engineering, the elimination of hexavalent chromium from aqueous media is a noteworthy field of study. In this regard, nanoparticle science and technology have contributed significantly to the photocatalytic reduction of Cr(vi).

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Background: Adult humeral shaft fractures have traditionally been managed conservatively, but surgical intervention is considered for displaced fractures or when conservative treatment is unlikely to be successful. The optimal surgical approach remains controversial, with open reduction and internal fixation (ORIF) using plates and screws considered the gold standard. However, concerns about soft tissue damage have led to the development of less invasive techniques, such as anterior bridge plating using minimally invasive plate osteosynthesis (MIPO).

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Diffusive memristors owing to their ability to produce current spiking when a constant or slowly changing voltage is applied are competitive candidates for development of artificial electronic neurons. These artificial neurons can be integrated into various prospective autonomous and robotic systems as sensors, e.g.

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Article Synopsis
  • - The "One Health" approach combines human, animal, and environmental health to tackle diseases, and this study specifically examines its application in southeast Asia for diseases like brucellosis, anthrax, and scrub typhus.
  • - Researchers reviewed 711 articles and included ten studies, focusing on key strategies such as collaboration between sectors, vaccination programs, and surveillance systems to monitor health in both humans and animals.
  • - The findings indicate that while some advancements have been made, a more integrated "One Health" strategy is essential for effectively preventing and managing zoonotic diseases, emphasizing the importance of stronger partnerships across different sectors.
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Introduction: This study explores potential application of silver nanoparticles (AgNPs) to treat periodontal infection using leaf extract. The eco-friendly green synthesis process uses as a natural stabilizer and reducer, allowing AgNPs to be formed.

Methods: Experimental AgNPs were characterized through transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), Zeta potential, ultraviolet-visible spectroscopy (UV-Vis) etc.

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Introduction: Non-fermenting gram-negative bacilli (NFGNB) infections have emerged as a serious health concern in ICUs. Multi-drug resistant (MDR) strains of NFGNB can evolve by acquiring resistance genes to at least one agent in three or more antibacterial categories. This study aimed to analyse the prevalence of NFGNB, the distribution of MDR strains, and antibiotic resistance trends of NFGNB in different ICUs of a tertiary care hospital over a period of five years.

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The development of fetal organs can be impacted by systemic changes in maternal circulation, with the placenta playing a pivotal role in maintaining pregnancy homeostasis and nutrient exchange. In clinical obstetrics, oxytocin (OXT) is commonly used to induce labor. To explore the potential role of OXT in the placental homeostasis of OXT, we compared OXT levels in neonatal cord blood among neonates (23-42 weeks gestation) whose mothers either received prenatal OXT or experienced spontaneous labor.

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Intracranial EEG is used for two main purposes: to determine (i) if epileptic networks are amenable to focal treatment and (ii) where to intervene. Currently, these questions are answered qualitatively and differently across centres. There is a need to quantify the focality of epileptic networks systematically, which may guide surgical decision-making, enable large-scale data analysis and facilitate multi-centre prospective clinical trials.

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Article Synopsis
  • The study focuses on developing advanced diagnostic tools for hepatitis B virus (HBV) and hepatitis C virus (HCV) using CRISPR technology for effective disease management.
  • Researchers created and tested guide RNAs that successfully target these viruses, leading to the development of a lateral flow assay (LFA) that detects both with high sensitivity and no cross-reactivity with other viruses.
  • By employing a dual-enzyme approach and creating a dual antigen detection LFA strip, the study demonstrates a promising method for rapid point-of-care diagnostics that can identify both infections simultaneously.
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