Effects of spiperone on feeding performance in a food preference test.

Spiperone reduced latency to feed and prolonged the total duration of feeding in a food-preference test in which novel and familiar foods were presented simultaneously to food-deprived rats. The increase in feeding duration could be accounted for in terms of an increase in time devoted to eating the novel foods, leaving the time devoted to eating the familiar food relatively unaltered. However, closer analysis of the data revealed that, at the level of mean duration of individual eating episodes, spiperone prolonged the eating-episode duration equally for both novel and familiar foods.

Adenylation and ADP-ribosylation in the mouse 1-cell embryo.

The incorporation of [3H]AAadenosine into cold trichloroacetic acid (TCA) insoluble material by the mouse 1-cell embryo has been studied. Incorporation of label was high immediately after fertilization, then decreased over the next 7 h with the sharpest decline occurring 3-5 h after fertilization. A small maximum was observed at the time of pronuclear DNA synthesis.