Publications by authors named "Swee Lin G Chen Yi Mei"
Improved blood tests assessing the functional status of rare gluten-specific CD4+ T cells are needed to effectively monitor experimental therapies for coeliac disease (CD). Our aim was to develop a simple, but highly sensitive cytokine release assay (CRA) for gluten-specific CD4+ T cells that did not require patients to undergo a prior gluten challenge, and would be practical in large, multi-centre clinical trials. We developed an enhanced CRA and used it in a phase 2 clinical trial ("RESET CeD") of Nexvax2, a peptide-based immunotherapy for CD.
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- Researchers wanted to see how liver health changed over 10 years in people with chronic hepatitis C, especially those who had treatment that worked (SVR).
- They looked at 131 patients, many of whom had their liver checked twice: once before 2004 and then again over a decade later.
- The study found that while some patients who achieved SVR maintained their liver health, more people overall developed serious liver issues over time.
Background: Mechanisms by which spontaneous clearance of acute hepatitis C occurs are unclear. A critical role for the innate immune system and IFNL4 polymorphisms has been proposed. This study investigates whether Toll-like receptor (TLR) expression and signaling during acute hepatitis C correlates with clinical outcomes.
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