Publications by authors named "Swee Chuan Tan"
Article Synopsis
- Sox6 plays a key role in determining muscle fiber types in vertebrates, specifically being repressed in slow-twitch muscle progenitors by the transcription factor Prdm1a.
- Researchers identified specific sequences in the sox6 gene that promote fast-twitch muscle expression when Prdm1a is active.
- While sox6 transcription is eventually derepressed in slow-twitch fibers, the protein itself is limited to fast-twitch fibers, regulated by miR-499, which is also controlled by Prdm1a, creating a feedback mechanism for slow-twitch muscle development.
