Publications by authors named "Swayamprabha Samantaray"
Women Health
January 2025
Article Synopsis
- - The study investigates the genetic connections between endometrial cancer (EC), endometriosis (ENDO), and obesity (OBY) to identify potential therapeutic targets by analyzing gene expression data.
- - A total of 26 shared differentially expressed genes were found, with IGF-1, CREBBP, EP300, and PIAS1 being key genes linked to disease mechanisms and survival outcomes.
- - Elevated IGF-1 levels in EC patients are associated with worse survival rates, indicating it may serve as a prognostic marker and highlighting the need for targeted therapies based on genetic findings.
Mol Genet Genomics
October 2024
Article Synopsis
- - Visceral obesity (VO) is linked to increased risks for both benign uterine leiomyoma (ULM) and malignant uterine leiomyosarcoma (ULS), but the specific molecular mechanisms connecting these conditions remain largely unknown.
- - This study used bioinformatics to analyze gene expression data and found 37 overlapping differentially expressed genes (DEGs) among VO, ULM, and ULS, with implications for cell proliferation and immune responses.
- - The research identified 14 key hub genes, including TOP2A, APOE, and TYMS, and revealed 26 FDA-approved drugs that could potentially target these genes, suggesting new avenues for treatment that need further experimental validation.
