Magnetic Anisotropic Effects in Charged Aza[10]annulene Analogs with a Non-planar Carbon Framework.

Classically, aromaticity portrays the unique stability and peculiar reactivities of cyclic planar conjugated systems with (4n+2) π electrons. Understanding the electronic environments in new chemical frameworks through experimental and theoretical validation is central to this ever-expanding theme in chemical science. Such investigations in curved π-surfaces have special significance as they can unravel the variations when the planarity requirement is slightly lifted.

Diffuse pleural metastasis from atypical meningioma.

Meningioma is the most common benign primary brain tumour and does not usually metastasise. We report the case of a 69-year-old male patient with a history of meningioma who presented respiratory symptoms. He was found to have diffuse pleural metastasis from meningioma, which occurred 10 years after surgical management of recurrent meningioma.

The Colossal Mandibular Ameloblastoma: Surgical Challenges and Current Perspectives of Management.

Ameloblastoma is the most common aggressive benign odontogenic tumour of the jaws. Ameloblastoma is a benign epithelial odontogenic tumour that typically arises in the mandible or maxilla. A clinical, radiographic and histopathological report is presented of a case of giant acanthomatous ameloblastoma in the left hemi mandible of a 46-year-old healthy lady.

Real-World Effectiveness of COVID-19 Vaccine and Identification of SARS-CoV-2 Variants among People Living with HIV on Highly Active Antiretroviral Therapy in Central Kerala of India-An Ambi-Directional Cohort Study.

Background: Vaccine effectiveness for first-generation coronavirus disease (COVID-19) vaccines among People Living with HIV (PLHIV) in India remains unexplored. This study entails the estimation of the real-world effectiveness of COVID-19 vaccines (AZD1222/Covishield, BBV152/Covaxin) among PLHIV and the identification of variants of SARS-CoV-2 among those infected with COVID-19.

Methods: An ambi-directional cohort study was conducted among 925 PLHIV above 18 years of age in two districts of central Kerala, India, from February 2022 to March 2023.

Liposomal drug delivery to the lungs: a post covid-19 scenario.

High local delivery of anti-infectives to the lungs is required for activity against infections of the lungs. The present pandemic has highlighted the potential of pulmonary delivery of anti-infective agents as a viable option for infections like Covid-19, which specifically causes lung infections and mortality. To prevent infections of such type and scale in the future, target-specific delivery of drugs to the pulmonary region is a high-priority area in the field of drug delivery.

Supramolecular Recognition of Cytidine Phosphate in Nucleotides and RNA Sequences.

Supramolecular recognition of nucleotides would enable manipulating crucial biochemical pathways like transcription and translation directly and with high precision. Therefore, it offers great promise in medicinal applications, not least in treating cancer or viral infections. This work presents a universal supramolecular approach to target nucleoside phosphates in nucleotides and RNA.

Boat and Chair Shaped Hexahalogen Synthons.

Non-covalent halogen bonding interactions are quintessential in crystal engineering for the construction of distinctive supramolecular synthons. Here, we report the first crystalline evidences of unique boat and chair shaped cyclic hexahalogen synthons in the crystal structures of α,α,α',α',4-pentabromo-o-xylene (PBX) and α,α,α',α',4,5-hexabromo-o-xylene (HBX) respectively. Nature and stability of constituent interactions in the supramolecular synthons are scrutinized with the help of quantum-chemical calculations.

Effects of phytoestrogens on reproductive organ health.

Phytoestrogens are non-steroidal, polyphenolic compounds that are derived from plants and have biological properties similar to those of human estrogens. Their bioactivity, which is based on the core ring system, is caused by their structural resemblance to estrogen. Flavonoids, coumestans, lignans, and stilbenes are the four major categories into which they can be divided.

Anthracene-Fused Oligo-BODIPYs: A New Class of π-Extended NIR-Absorbing Materials.

Large π-conjugated systems are key in the area of molecular materials. Herein, we prepare via Au -catalyzed cyclization a series of fully π-conjugated anthracene-fused oligo-BODIPYs. Their structural and optoelectronic properties were studied by several techniques, ranging from X-ray, UV/Vis, and cyclic voltammetry to transient absorption spectroscopy.

To tread or not to tread: comparison between water treading and conventional flapping wing kinematics.

Hovering insects are limited by their physiology and need to rotate their wings at the end of each back-and-forth motion to keep the wing's leading edge ahead of its trailing edge. The wing rotation at the end of each half-stroke pushes the leading edge vortex away from the wing which leads to a loss in the lift. Unlike biological fliers, human-engineered flapping wing micro air vehicles have different design limitations.

Retaining Hückel Aromaticity in the Triplet Excited State of Azobenzene.

The implication of the potential concept of aromaticity in the relaxed lowest triplet state of azobenzene, an efficient molecular switch, using elementary aromaticity indices based on magnetic, electronic, and geometric criteria has been discussed. Azobenzene exhibits a major Hückel aromatic character retained in the diradical lowest relaxed triplet state (T ) by virtue of a twisted geometry with partial delocalization of unpaired electrons in the perpendicular p-orbitals of two nitrogen atoms to the corresponding phenyl rings. The computational analysis has been expanded further to stilbene and N-diphenylmethanimine for an extensive understanding of the effect of closed-shell Hückel aromaticity in double-bond-linked phenyl rings.

Geographic Pattern of Typhoid Fever in India: A Model-Based Estimate of Cohort and Surveillance Data.

Background: Typhoid fever remains a major public health problem in India. Recently, the Surveillance for Enteric Fever in India program completed a multisite surveillance study. However, data on subnational variation in typhoid fever are needed to guide the introduction of the new typhoid conjugate vaccine in India.

Antibiotics for Fever Among Children: Findings From the Surveillance for Enteric Fever in India Cohorts.

Background: Acute febrile illness in children is frequently treated with antibiotics. However, the inappropriate use of antibiotics has led to the emergence of multidrug-resistant pathogens.

Methods: We measured use of antibiotics for fever in 4 pediatric cohorts that were part of the Surveillance for Enteric Fever in India (SEFI) network.

Tetrahydrobiopterin and Its Multiple Roles in Neuropsychological Disorders.

Tetrahydrobiopterin (BH4) is a multifunctional co-factor of various enzymes and a substantial amount of studies have shown BH4 as a key regulator in the synthesis of neurotransmitters such as serotonin, nor-epinephrine as well as dopamine. The imbalance of BH4 may affect neurotransmitter production which can lead to many abnormalities in CNS. This article reviews the role of BH4 in neurodegenerative and neurodevelopmental disorders.

Active Symptom-Based Surveillance of Adverse Events Following Immunization Among Individuals Vaccinated with ChAdOx1 nCoV-19 Coronavirus Vaccine in a Tertiary Hospital of Kerala.

Background: The reports on adverse experiences following vaccination are scanty from India. It is important to know the real-world post-vaccination experience outside of clinical trial conditions.

Objectives: The study aims to estimate the incidence of adverse events following immunization with the ChAdOx1 nCoV-19 coronavirus vaccine and to identify the predictors for the development of vaccine adverse events.

Diastereoselective formation of homochiral flexible perylene bisimide cyclophanes and their hybrids with fullerenes.

Cyclophanes of different ring sizes featuring perylene-3,4:9,10-tetracarboxylic acid bisimide (PBI) linked by flexible malonates were designed, synthesized, and investigated with respect to their structural, chemical and photo-physical properties. It is predominantly the number of PBIs and their geometric arrangement, which influence dramatically their properties. For example, two-PBI containing cyclophanes reveal physico-chemical characteristics that are governed by strong co-facial π-π interactions.

Dietary foods containing nitric oxide donors can be early curators of SARS-CoV-2 infection: A possible role in the immune system.

Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) is a lethal virus that causes COVID-19 (Coronavirus disease 2019), the respiratory illness that has caused the COVID-19 pandemic. Even though multiple pharmacological trials are ongoing, there is no proof that any treatment will effectively cure or prevent COVID-19. Currently, COVID-19-infected patients are being managed with non-specific medications to suppress the symptoms and other associated co-morbidities.

Unmasking the human face of TB- The impact of tuberculosis on the families of patients.

Background: As per the World Health Organization (WHO) Global Report 2017, among the 9.6 million cases of tuberculosis (TB) that occur annually in the world, 2.8 million are found in India.

Wing Design in Flies: Properties and Aerodynamic Function.

The shape and function of insect wings tremendously vary between insect species. This review is engaged in how wing design determines the aerodynamic mechanisms with which wings produce an air momentum for body weight support and flight control. We work out the tradeoffs associated with aerodynamic key parameters such as vortex development and lift production, and link the various components of wing structure to flight power requirements and propulsion efficiency.

Photoactive preorganized subphthalocyanine-based molecular tweezers for selective complexation of fullerenes.

The development of new chromophoric receptors capable of binding curved carbon nanostructures is central to the quest for improved fullerene-based organic photovoltaics. We herein report the synthesis and characterization of a subphthalocyanine-based multicomponent ensemble consisting of two electron-rich SubPc-monomers rigidly attached to the convex surface of an electron-poor SubPc-dimer. Such a unique configuration, especially in terms of the two SubPc-monomers, together with the overall stiffness of the linker, endows the multicomponent system with a well-defined tweezer-like topology to efficiently embrace a fullerene in its inner cavity.

Nanoscale LuFeO: shape dependent ortho/hexa-phase constitution and nanogenerator application.

In multiferroic LuFeO the hexagonal (-h) phase is an intermediate metastable phase encountered during the amorphous to orthorhombic (-o) transformation and is ferroelectric in nature. Thus far it has only been stabilized in a substrate-supported few layered ultrathin film form. Herein we show that the surface-induced strain field intrinsically present in nano-systems can self-stabilize this phase and the hexagonal to orthorhombic phase constitution ratio depends on the shape of the nanomaterial.

Rare case of transverse testicular ectopia - Case report and review of literature.

Unlabelled: This case report has been reported in line with the SCARE criteria; Consensus-based surgical case report guidelines of International Journal of Surgery 2016.

Introduction: Transverse Testicular Ectopia (TTE) is a rare condition which manifests with unilateral undescended testis and contralateral hernia. Till now around 100 cases have been described in the literature.