Publications by authors named "Swathi Banapuram"

Vascular Endothelial Growth Factor Receptor 1 (VEGFR1), is an enzyme with tyrosine kinase activity that plays a pivotal role in angiogenesis, the process of new blood vessel formation. This receptor is of significant clinical importance as it is implicated in various cancers, particularly non-small cell lung cancer (NSCLC), where its dysregulation leads to uncontrolled cell growth through ligand-induced phosphorylation. While commercially available drugs target VEGFR1, their prolonged use often leads to drug resistance and the emergence of mutations in cancer patients.

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Cancer cell heterogeneity (CCH) is crucial in understanding cancer progression and metastasis. The CCH is one of the stumbling blocks in modern medicine's therapeutics and diagnostics . An in-vitro model of co-culture systems of MCF-7, HeLa, HEK-293, with THP-1 cells showed the occurrence of EpCAM positive (EpCAM+) and EpCAM negative (EpCAM-) heterogenetic cancer cell types labeled with the Quantum Dot antibody conjugates (QD).

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Quantum dots (QD) with chemical composition were successfully synthesized using a hydrothermal method and chemical precipitation. The nanocrystalline phase of the nanostructures was isolated and characterized using X-ray diffraction (XRD). The mean crystalline size doped core/shell Ni-dopant range was 9.

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Background: The genetic association studies of type 2 diabetes mellitus (T2DM) hitherto undertaken among the Indian populations are grossly inadequate representation of the ethnic and geographic heterogeneity of the country. In view of this and due to the inconsistent nature of the results of genetic association studies, it would be prudent to undertake large scale studies in different regions of India considering wide spectrum of variants from the relevant pathophysiological pathways. Given the reproductive dysfunctions associated with T2DM, it would be also interesting to explore if some of the reproductive pathway genes are associated with T2DM.

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Article Synopsis
  • - The study investigates the genetic variations of the eNOS gene (specifically the -786T/C, Intron 4b/4a, and 894G/T polymorphisms) and their link to the higher prevalence of Coronary Heart Disease (CHD) among young Indians and their first-degree relatives (FDRS).
  • - Results reveal that FDRS and CHD patients exhibit significantly higher risk factors (like obesity and family history) compared to healthy controls, alongside notable differences in eNOS genotype frequencies.
  • - The findings highlight the critical role of eNOS variations in CHD development and suggest potential for predicting coronary risks and developing preventative treatments for at-risk individuals.
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