Publications by authors named "Swasati Handique"

The COVID-19 significantly impacted older adults, worsening their physical health and social connectedness. This study examined whether social support mediates the correlation between COVID-19 concerns and self-rated physical health (SRPH) using data from 2672 participants (aged 50-99) in the NSHAP COVID-19 sub-study (2019-20). Mediation analysis revealed that COVID-19 concerns significantly predicted lower perceived social support (b = -0.

View Article and Find Full Text PDF
Article Synopsis
  • Neuronal Ceroid Lipofuscinosis (NCL) are lysosomal storage disorders leading to neurodegeneration, with adult-onset Kufs disease having distinct characteristics like later onset and preserved vision.
  • The authors describe three siblings diagnosed with a novel pathogenic CLN5 subtype, showing symptoms like developmental regression and drug-resistant myoclonic epilepsy, typical of Kufs A.
  • This case highlights the increasing recognition of genotypic-phenotypic variations in NCL, as these siblings had an unusual presentation of Kufs A with severe epilepsy.
View Article and Find Full Text PDF

In the present time, microplastics (MPs) are a cause of growing concern in freshwater environments throughout the globe. Flood accelerates the transport of MPs from river into the marine environment. However, there is a lack of research on the impact of flood on microplastic abundance and distribution in Indian rivers.

View Article and Find Full Text PDF

The αA-crystallin protein plays a vital role in maintaining the refractive index and transparency of the eye lens. Significant clinical studies have emerged as the αA-crystallin is prone to aggregation, resulting in the formation of cataracts with varied etiologies due to mutations. This work aims to comprehend the structural and functional role of cataract-causing mutations in αA-crystallin, particularly at N-Terminal and α-Crystallin Domains, using in-silico approaches including molecular dynamics simulation.

View Article and Find Full Text PDF

Microplastics (MPs) are increasingly recognized as environmental contaminants with complex impacts on fish and other aquatic organisms. This study determined the microplastics abundance and the induced-ecological risks of microplastics in water, sediment, and commonly harvested fishes of a Ramsar site, Deepor Beel of Assam, India. Six samples of water and sediment were collected with nine individuals of two commonly harvested fish species Puntius sophore (Pool Barb) and Gudusia chapra (Indian River Shad).

View Article and Find Full Text PDF

Introduction: Vitamin D's precise role in bone mineral density regulation remains elusive. Nevertheless, its deficiency is linked to increased bone turnover through the upregulation of RANK ligands by osteoblasts. This study aimed to (i) evaluate vitamin D status in young adults and (ii) assess the association between vitamin D deficiency and bone turnover markers receptor activator of nuclear factor-κB ligand (RANKL), RANK, and the osteoprotegerin (OPG) in determining bone mineral density.

View Article and Find Full Text PDF

Introduction: In recent times, there has been a surge in proposed alternative approaches to computing low-density lipoprotein cholesterol (LDL-C), with a focus on enhancing precision, particularly within diverse demographic and clinical groups. Our aim is to assess the agreement, precision, and practicality of these methods compared to direct LDL-C measurements, with the goal of identifying the most effective approach for estimating LDL-C in the Indian context.

Methods: It is a retrospective analytical study.

View Article and Find Full Text PDF

Introduction: During orthodontic treatment, temporary anchoring devices (TADs) are used to restrain tooth movement. They are a relatively recent addition to the dental toolkit.

Aim: As TADs have limitations, Dr.

View Article and Find Full Text PDF

Severe typical deep-pitted lesions of Potato Common Scab (PCS) disease were observed in two locations in China, Dingxi, Gansu Province, and Shuozhou, Shaanxi Province, in 2021. Potato farms in Dingxi growing cultivar Huangxin 226 (26 hectares) exhibited a scab disease incidence of 10%, while cultivar Jinshu 15# (4 hectares) in Shuozhou showed a disease incidence of 30% (Fig. 1).

View Article and Find Full Text PDF

Bacteriophages have emerged as promising alternatives to pesticides for controlling bacterial pathogens in crops. Among these pathogens, Streptomyces stelliscabiei (syn. S.

View Article and Find Full Text PDF

Curcumin conjugated heterocyclic compounds are potent candidates with drug likeness against various bacterial pathogens. A set of curcumin-based pyrrole conjugates (CPs) were synthesized and characterized by FT-IR, H and C NMR and HR-MS techniques. The results of free radical scavenging activity of the synthesized CPs, evaluated by FRAP and CUPRAC assays, showed the potency of these compounds as effective antioxidants.

View Article and Find Full Text PDF

spp. are the primary causative agents of aerial stem rot in potatoes in China. A nationwide survey revealed the widespread occurrence of aerial stem rot in the northern, southern, and southwestern cultivation regions, with occurrence rates ranging from 1 to 60%.

View Article and Find Full Text PDF

The study investigated the influence of a National Highway (NH) traversing tea estates (TEs) on heavy metal (HM) contamination in the top soils of Upper Assam, India. The dispersion and accumulation of six HMs, viz. cadmium (Cd), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), and zinc (Zn), within tea-growing soils were assessed using diverse indices: contamination factor (CF), degree of contamination (DC), enrichment factor (EF), geo-accumulation index (I), modified degree of contamination (MDC), Nemerow pollution index (PI), pollution load index (PLI), potential ecological risk factor (E), and potential ecological risk index (RI).

View Article and Find Full Text PDF

also known as water spinach, is an aquatic non-conventional leafy vegetable and is considered a healthy and seasonal delicacy in ethnic food culture. The study revealed the presence of rich chemical and biochemical composition in and antioxidant activities. Moreover, the plant extracts demonstrated significant DNA damage prevention activity against UV/HO-induced oxidative damage.

View Article and Find Full Text PDF

Abernathy malformations are congenital extrahepatic porto-systemic shunts which allow splanchnic circulation to bypass the metabolic screen of the liver and drain directly into the systemic circulation. The resulting metabolic abnormalities have a multitude of implications ranging from hyperammonaemia, hepatic encephalopathy, to pulmonary hypoxemia. The shunt also causes anatomical implications in the form of varices.

View Article and Find Full Text PDF

With increased efficiency, simplicity in manufacturing, adaptability, and flexibility, solar cells constructed from organic metal halide perovskite (PVK) have recently attained great eminence. Lead, a poisonous substance, present in a conventional PVK impacts the environment and prevents commercialization. To deal with this issue, a number of toxicity-free PVK-constructed solar cells have been suggested.

View Article and Find Full Text PDF

Due to smaller particle size (0.1 µm-5 mm), non-biodegradable or slowly degradable nature, and high accumulation capacity in the environment, microplastics are becoming a cause of concern throughout the globe. The abundance and distribution of microplastics in aquatic compartments are strongly influenced by various natural and anthropogenic variables.

View Article and Find Full Text PDF

Soft rot enterobacterial plant pathogens Pectobacterium spp. and Dickeya spp. have caused devastating blackleg, aerial stem rot, and soft rot of potato tubers (Charkowski 2018).

View Article and Find Full Text PDF

Multiple species of Streptomyces cause common scab disease in potato (Solanum tuberosum) (Kämpfer et al. 1991). Potato tubers (cv.

View Article and Find Full Text PDF

Lupus nephrtis in children is associated with high morbidity and mortality. The incidence of childhood systemic lupus erythematosus (SLE) ranges from 3.3 to 8.

View Article and Find Full Text PDF

A field study was conducted from 0 to 360 days to investigate the effect of tea pruning litter biochar (TPLBC) on the accumulation of major micronutrients (copper: Cu, manganese: Mn, and zinc: Zn) in soil, their uptake by tea plant (clone: S.3 A/3) and level of contamination in soil due to TPLBC. To evaluate the level of contamination due to TPLBC, a soil pollution assessment was carried out using the geo-accumulation index (I), enrichment factor (EF), contamination factor (CF), potential ecological risk factor (PERF), individual contamination factor (ICF), and risk assessment code (RAC).

View Article and Find Full Text PDF

The study attempts to look into the morphological characteristics, elemental composition, contamination, source contributions, and associated health risks in household dust of Napaam, a rural region in the Brahmaputra flood plain in North East India. Morphological evidence suggests that most of the house dust particles were sourced from vehicle abrasion and soil. Three contamination indices-enrichment factor (EF), index of geo-accumulation (I), and pollution load index (PLI) indicated that Cl and four trace elements (Cu, Zn, As, and Pb) are significantly enriched in house dust with extreme pollution load.

View Article and Find Full Text PDF