Proximal-type epithelioid sarcoma of the maxilla with metastasis to the scalp: Cytologic findings of an unusual malignant tumor.

Epithelioid sarcoma of proximal type (ESPT), a subtype of epithelioid sarcoma, is an uncommon malignant neoplasm of the soft tissue with histo- and cytologic features similar to epithelioid sarcoma, classic type and to the more commonly encountered extra-renal malignant rhabdoid tumor (EMRT). Unlike classic epithelioid sarcoma, ESPT usually involves pelvic, perineal, and genital regions and has an aggressive clinical course. Like EMRT, ESPT can have aberrations of the INI1 gene on chromosome 22q, which results in the loss of INI1 protein expression.

Cytology of a sarcomatoid renal cell carcinoma with unusual coexpression of S-100 protein: a case report, review of the literature and cytologic-histologic correlation.

Sarcomatoid renal cell carcinoma (SRCC) is an aggressive variant of renal cell carcinoma; it is an uncommon, malignant neoplasm, and its diagnosis is usually based on the histologic evaluation of a nephrectomy specimen. Patients are treated with systemic therapy and, generally, a nephrectomy is not performed. Therefore, arriving at an accurate diagnosis is critical for planning further management.

Multiple pilomatrixomas: case report and literature review.

Pilomatrixoma is a rare, benign, circumscribed, calcifying epithelial neoplasm that is derived from hair matrix cells. Multiple pilomatrixomas are uncommon. We describe a case of multiple pilomatrixomas in a 23-year-old black woman who presented with lesions on her face and back.

Do cytogenetic abnormalities precede morphologic abnormalities in a developing malignant condition?

Cytogenetic evaluation of bone marrow and neoplastic tissues plays a critical role in determining patient management and prognosis. Here, we highlight two cases in which the cytogenetic studies challenge the common practice of using hematologic and morphologic changes as key factors in malignant disease management. The first case is that of a lymph node sample from a 40-yr-old non-Hodgkin's lymphoma (NHL) patient sent for determination of disease progress.

The effects of intradermal and topical mitomycin C on wound healing.

Objective: To determine the effect of intradermal and topical mitomycin C (MMC) on skin wound healing.

Study Design/setting: A prospective, controlled study in a rat wound model performed in an academic medical center.

Results: Intradermal and topical MMC application decreased wound integrity when compared with saline-treated animals at 1 week, 2 weeks, 1 month, and 6 months.