Publications by authors named "Swarnendu Sen"

Sonodynamic therapy (SDT) is a minimally invasive targeted cancer therapy that uses focused low-intensity ultrasound (<10 MPa, <10 W/cm) to activate sonosensitizer drugs. Once activated, these chemical compounds generate reactive oxygen species (ROS) to damage and kill cancer cells. A Phase I clinical trial has shown promising results for treating glioblastoma with SDT.

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Article Synopsis
  • - Bioaerosols generated in the respiratory system are significant for spreading infectious diseases like common cold, influenza, and COVID-19, highlighting the need to study their production mechanisms.
  • - A computational study investigates bioaerosol production resulting from air interacting with a mucus layer in the respiratory tract, revealing that specific fluid dynamics cause instability that can lead to bioaerosol formation.
  • - The research finds that bioaerosols can form even during normal breathing, depending on mucus properties, and that these aerosols are larger and less numerous than those produced during coughing, suggesting implications for treatment strategies.
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Modern lean premixed combustors are operated in ultra-lean mode to conform to strict emission norms. However, this causes the combustors to become prone to lean blowout (LBO). Online monitoring of combustion dynamics may help to avoid LBO and help the combustor run more safely and reliably.

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A natural circulation system (NCS) has a broad application in the sector of thermal engineering, for example, in nuclear reactors due to its capability in transferring heat without any support of external power or a mechanical device. NCSs, although designed for steady operation, have been found to exhibit dynamical behavior, such as periodic oscillations, depending on the input heater power. The heater power, otherwise assumed to be steady, can be fluctuating in practice.

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Lean premixed combustors are highly susceptible to lean blowout flame instability, which can cause a fatal accident in aircrafts or expensive shutdown in stationary combustors. However, the lean blowout limit of a combustor may vary significantly depending on a number of variables that cannot be controlled in practical situations. Although a large literature exists on the lean blowout phenomena, a robust strategy for early lean blowout detection is still not available.

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Non-metallic oxide nanofluids have recently attracted interest in pool boiling heat transfer (PBHT) studies. Research work on carbon and silica-based nanofluids is now being reported frequently by scholars. The majority of these research studies showed improvement in PBHT performance.

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Inverse diffusion flame (IDF) is a reliable low NO technology that is suitable for various industrial applications including gas turbines. However, a confined IDF may exhibit thermoacoustic instability, a kind of dynamic instability, which is characterized by catastrophically large amplitude pressure oscillations. Transition to such instability for an inverse diffusion flame is less explored compared to other types of flame.

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Lean blowout (LBO) is a serious issue in modern gas turbine engines that operate in a lean (premixed) mode to follow the stringent emission norms. When an engine operates with a lean fuel-air mixture, the flame becomes unstable and is at times carried out of the combustion chamber by the unburnt flow. Thus, the sudden loss of the flame, known as lean blowout, leads to fatal accidents in aircrafts and loss of production in power plants.

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With the rapid spread of COVID-19 worldwide, the demand for appropriate face masks in the market has also skyrocketed. To ease strain on the supply of masks to the essential healthcare sector, it has become imperative that ordinary people rely more on home-made masks that can be easily put together using commonly available materials, while at the same time performing reasonably at arresting the ingress or egress of airborne droplets. Here, we propose a simple do-it-yourself (DIY) method for preparing a three-layered face mask that deploys two hydrophobic polypropylene nonwoven layers interspaced with a hydrophilic cellulosic cloth.

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In order to improve the inherently poor mechanical properties of hydroxyapatite (HAp) and to increase its feasibility as load bearing implant material, in the present investigation, functionalised (HFC1 and HFC2) and non-functionalized (HC1 and HC2) multi-walled carbon nanotubes were used as reinforcing material with HAp. Significant improvement with respect to fracture toughness, flexural strength and impact strength of the composites was noticed. In vitro biological properties of HAp-carbon nanotube (CNT) biocomposites have also favored uniform and systematic apatite growth on their surface.

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Synopsis of recent research by authors named "Swarnendu Sen"

  • - Swarnendu Sen's recent research focuses on the intersection of fluid dynamics and biomedical applications, including studies on sonodynamic therapy for cancer treatment using lipid-coated microbubbles and bioaerosol formation in the respiratory tract, emphasizing their implications for disease transmission.
  • - His work also delves into combustion dynamics, particularly in lean premixed combustors, where he employs innovative techniques such as topological data analysis and recurrence network analysis to enhance detection and understanding of lean blowout phenomena, crucial for aviation and energy sectors.
  • - Additionally, Sen explores advanced materials in engineering, including the use of carbon nanotube-reinforced hydroxyapatite for improved bone regeneration and the development of DIY face masks leveraging wettability engineering during the COVID-19 pandemic, showcasing his versatility across multiple fields of research.