Publications by authors named "Swarajit N Ghosh"
The goal of these studies was to characterize the infiltrating inflammatory cells during pneumonitis caused by moderate doses of radiation. Two groups of male rats (WAG/RijCmcr, 8 weeks old) were treated with single 10- or 15-Gy doses of thoracic X radiation; a third group of age-matched animals served as controls. Only 25% rats survived the 15-Gy dose.
View Article and Find Full Text PDFRenin-Angiotensin system suppression mitigates experimental radiation pneumonitis.
Int J Radiat Oncol Biol Phys
December 2009
Purpose: To find the mitigators of pneumonitis induced by moderate doses of thoracic radiation (10-15 Gy).
Methods And Materials: Unanesthetized WAG/RijCmcr female rats received a single dose of X-irradiation (10, 12, or 15 Gy at 1.615 Gy/min) to the thorax.
Article Synopsis
- The study aimed to understand the effects of a single dose of whole-thorax irradiation in rats, simulating potential injuries from a nuclear incident.
- Rats exposed to 10 Gy of X-rays showed significant changes like increased breathing rate, decreased oxygen levels, and lung fluid changes, unlike those exposed to 5 Gy.
- While initial damage like edema occurred, mild fibrosis developed after 20 weeks, indicating that lung function gradually improved over time despite the higher radiation dose.
Purpose: To investigate whether irradiating small lung volumes with a large dose or irradiating large lung volumes with a small dose, given the same mean lung dose (MLD), has a different effect on pulmonary function in laboratory animals.
Methods And Materials: WAG/Rij/MCW male rats were exposed to single fractions of 300 kVp X-rays. Four treatments, in decreasing order of irradiated lung volume, were administered: (1) whole lung irradiation, (2) right lung irradiation, (3) left lung irradiation, and (4) irradiation of a small lung volume with four narrow beams.