The extended use of ethambutol beyond 2 months for treating tuberculosis has increased risk of optic neuropathy. We performed a systematic review of studies evaluating optic neuropathy in extended ethambutol use since 2010 and compared the outcome with a similar systematic review (1965-2010) by Ezer et al. Literature search was conducted in PubMed, Medline, EMBASE, and Cochrane databases.
View Article and Find Full Text PDFPeripheral ulcerative keratitis (PUK) is an inflammatory, necrotic condition in the peripheral cornea which may end in corneal perforation and visual morbidity if not treated adequately. PUK can occur due to infectious or non-infectious causes. Early cases need medical therapy, both locally and systemically (for some cases).
View Article and Find Full Text PDFBackground: Opportunistic cases of rhino-orbito-cerebral mucormycosis (ROCM) have increased in India during the coronavirus disease 2019 (COVID-19) pandemic.
Aim: To study laboratory parameters, histopathological features of sinus mucosal biopsies and exenterated orbit specimens, and clinical aspects of patients with ROCM.
Materials And Methods: Retrospective analysis of nasal and sinus debridement biopsies and orbital exenteration specimens of 30 patients was undertaken, along with analysis of laboratory parameters, clinical history of predisposing conditions, and medication history during COVID-19.
The COVID-19 pandemic has impacted transplantation worldwide in a major way with infections and post-COVID-19 complications contributing to increased mortality and morbidity. We present a case of a 42-year-old lady who developed rhino-orbital mucormycosis in a postliver transplantation period. The initial presentation of the patient was very subtle.
View Article and Find Full Text PDFScleritis is a rare painful ocular disorder, associated with severe ocular pain and tissue destruction. Although a majority of these cases are immune mediated and at least half of these are associated with systemic immune-mediated diseases, a smaller minority are due to infections of the sclera. The two conditions closely mimic each other, and a thorough knowledge of the subtle differences is necessary in order to reach a timely diagnosis.
View Article and Find Full Text PDFPurpose: To report the epidemiology of uveitis in two urban centers in South India.
Methods: Case records seen between January 2014 and December 2014 at two tertiary eye centers in South India were retrospectively reviewed.
Results: A total of 1123 patients in the study population had uveitis.
Aim: The aim of this study is to describe the clinical features and diagnostic criteria of Fuchs' uveitis (FU) and to determine whether it has an association with virus and toxoplasma in the aqueous humor during cataract surgery.
Setting And Design: This is a prospective, case-control study.
Materials And Methods: Patients with FU (n = 25), anterior uveitis (n = 15), and no uveitis (normal) (n = 50) were included based on predefined inclusion and exclusion criteria for all three groups.
Purpose: To describe the history, clinical features, and outcomes of a large case series of microsporidial stromal keratitis with emphasis on probable predictors of the etiology in this rare and unspecified form of keratitis.
Methods: Retrospective analysis of cases seen between January, 2002, and December, 2013, diagnosed at LV Prasad Eye Institute as having microsporidial stromal keratitis based on clinical, microbiology, and histopathology examination. Outcomes of medical and surgical management with visual recovery were documented.