Molecular Pathogenesis, Immunopathogenesis and Novel Therapeutic Strategy Against COVID-19.

The coronavirus disease 2019 (COVID-19), is a highly contagious transmittable disease caused by a recently discovered coronavirus, pathogenic SARS-CoV-2. Followed by the emergence of highly pathogenic coronaviruses in 2003 SARS-CoV, in 2012 MERS-CoV, now in 2019 pathogenic SARS-CoV-2, is associated with a global "pandemic" situation. In humans, the effects of these viruses are correlated with viral pneumonia, severe respiratory tract infections.

Influence of spacer length on the agglutination of glycolipid-incorporated liposomes by ConA as model membrane.

Through a systematic investigation of the agglutination of long chain mannolipid and glucolipid incorporated liposomes by concanavalin A (ConA) it was found that the agglutination was dependent on different factors. The studied factors reported here are (1) spacer length and (2) ground lipid matrix. The threshold and the relative saturating ConA binding concentration (saturation point to attain the binding saturation condition) of glycosides with varying spacer length for agglutination are dependent on the spacer length of the glycolipid.

Influence of spacer length on interaction of mannosylated liposomes with human phagocytic cells.

Purpose: To improve target specificity and uptake of liposomes by macrophages, one can improve high-affinity receptor binding to mannose determinants with their 175-kDa mannose receptor (MR), which is mainly influenced by the length and flexibility of the spacer between the carbohydrate head group and liposome surface. Liposomes containing alkylmannosides with hydrophilic spacers 0 to 8 ethyleneoxy units (EO) long (Man0..