Biofabrication of aminated nanocellulose reinforced polyvinyl alcohol/chitosan nanofibrous scaffold for sustained release of diltiazem hydrochloride.

In the modern environment conscious era, there has been a huge demand for the effective green method to fabricate biomaterials for sustained transdermal release of diltiazem hydrochloride to treat hypertension and cardiac failure. In this vein, the present study explores the amination of waste jute sourced nanocellulose (ANC) and its effect as a reinforcing filler to design electrospun polyvinyl alcohol (PVA)/chitosan based polymeric nanofibrous scaffold for drug delivery. The characterization results of FTIR (Fourier Transform Infrared Spectroscopy) confirm the successful chemical modification of nanocellulose (NCC).

Mycochemistry, antioxidant content, and antioxidant potentiality of the ethanolic extract of and its anti-cancerous effect on HeLa cancer cell line, and antitumor effect on HeLa-implanted mice.

Objectives: Cervical cancer is increasing worldwide and is becoming resistant to the existing drugs in clinical practice. Here, ethanolic extract of fruit body of was evaluated as antioxidant, anticancer agent against HeLa cell lines and anti-tumor against cervical cancer in mice model.

Methods: Fruit bodies of in 90% ethanol, and the ethanolic extract (PFEE) was subsequently investigated for its antioxidant content and activity, anticancer properties against the cervical cancer cell line, HeLa, and antitumor activity against HeLa implanted mice.

An eco-friendly approach of biocontrol of aphid (Aphis gossypii Glover) by Trichoderma harzianum.

Aphid (Aphis gossypii) is one of the important pests of papaya crop. In this work, applications of Trichoderma harzianum and Beauveria bassiana (biocontrol agents) and malathion (insecticide) were conducted in vitro and in agrifields for testing their anti-aphid efficacy and compared their efficacy. Furthermore, the enzymatic mechanism of T.

An insight of anopheline larvicidal mechanism of Trichoderma asperellum (TaspSKGN2).

Anopheline larvicidal property of T. asperellum has been found recently in medical science. The mechanism of actions exhibited by T.

Neem leaf glycoprotein salvages T cell functions from Myeloid-derived suppressor cells-suppression by altering IL-10/STAT3 axis in melanoma tumor microenvironment.

Myeloid-derived suppressor cells (MDSCs) suppress antitumor immune functions. We have observed that an immunomodulator, neem leaf glycoprotein (NLGP), inhibits tumor-resident MDSCs and enhances antitumor CD8+ T cell immunity. NLGP inhibits the number as well as functions of tumor-resident MDSCs (Gr1±CD11b±) and enhances antitumor CD8± T cell immunity by downregulating arginase 1 and inducible nitric oxide synthase production in MDSCs.

In target areas where human mosquito-borne diseases are diagnosed, the inclusion of the pre-adult mosquito aquatic niches parameters will improve the integrated mosquito control program.

In human communities inhabiting areas-such as West Bengal- India-where perpetuate the pre-imago & adult developmental stages of mosquitoes; many infectious diseases are still diagnosed such as Dengue, Malaria and Acute Encephalitis Syndrome. The control of the aquatic developmental stages is one of the easiest way to prevent the emergence of adults-the blood feeding adult females being thus prevented to sample their blood meal and to lay their eggs in the aquatic milieu where develop the aquatic pre-imaginal developmental stages. Moreover, reducing the adult population size also the probability of for the blood feeding adult female mosquitoes to act as hosts and vectors of the arboviruses such as dengue virus & Japanese encephalitis virus as well as of Plasmodium.

Anticancer Activity of Solvent Extracts of Hexogonia glabra against Cervical Cancer Cell Lines.

Objective: In this study, we aimed to harness some solvent extracts of one wild mushroom Hexagonia glabra and test their anti-cancer activity against cervical human cell lines, namelyHeLa, SiHa, and CaSki.

Methods: It includes cell morphological study by microscope, nuclear morphology by DAPI staining under fluorescence microscopy, apoptosis assay by fluorescence technique, anti-proliferation by MTT assay and expression of apoptotic and anti-apoptotic genes by Western blotting and cell cycle analysis was done.

Results: The selected cervical cancer cells were treated separately with 150 µg/mL of three extracts, namely of ethanolic (EE), ethyl acetate (EAE), and water extract (WE) and exhibited features like round, shrink and dead.

Reactivity Parameters and Substitution Effect in Organic Acids.

We investigate a few density functional theory-based reactivity indices of chemistry, with a view to arrive at an intercomparison and also consider their applications toward the problems of chemical significance. In particular, we propose to use the concepts of fugality and atom-atom polarizability to study the acidic strength of substituted benzoic acid derivatives. The nature of the variations and trends in the correlation of reactivity parameters and p values is shown to provide an insight into the applicability of these concepts to such reactions.

Smart Polyacrylate Emulsion Based on a New ABC-Type Triblock Copolymer via RAFT-Mediated Surfactant-Free Miniemulsion Polymerization: Its Multifunctional Properties.

The present investigation deals with the development of an acrylic-based polymeric emulsion that offers multifunctional properties such as superhydrophobic, antimicrobial, anti-icing, and self-cleaning. The said multifunctional waterborne emulsion was prepared via a surfactant-free reversible addition-fragmentation chain transfer (RAFT) polymerization technique. To accomplish this, a new class of ABC-type triblock copolymer (PMTAC--PBA--PIBA) based on 2-(methacryloyloxy) ethyl ammonium chloride (MTAC), -butyl acrylate, and isobornyl acrylate (IBA) was synthesized via a polymerization-induced self-assembly technique in a surfactant-free miniemulsion process.

Sustained release of ketorolac tromethamine from poloxamer 407/cellulose nanofibrils graft nanocollagen based ophthalmic formulations.

There has been extensive utilization of poloxamer 407 (PM) for the delivery of various ophthalmic drugs aimed at efficient ophthalmic drug delivery approach for longer precorneal residence time along with acceptable bioavailability of drugs. We have studied the effect of nanocellulose grafted collagen (CGC) on the performance of in situ gels based on PM for the controlled in vitro release of Ketorolac Tromethamine (KT). CGC has shown great influence evident by the reduction in PM critical gelation concentration, increased gel strength, and prolonged the release of loaded drugs compared with the virgin PM gel.

Silver nanoparticle-induced developmental inhibition of Drosophila melanogaster accompanies disruption of genetic material of larval neural stem cells and non-neuronal cells.

A few studies had determined the effects of silver nanoparticles on the development of Drosophila melanogaster. However, none had addressed its genotoxic effects on specific larval cells of the fly in details. This study was conducted to determine the effects of silver nanoparticle on the development of D.

Mathematical Modeling and Simulations for Large-Strain J-Shaped Diagrams of Soft Biological Materials.

Herein, we study stress⁻strain diagrams of soft biological materials such as animal skin, muscles, and arteries by Finsler geometry (FG) modeling. The stress⁻strain diagram of these biological materials is always J-shaped and is composed of toe, heel, linear, and failure regions. In the toe region, the stress is almost zero, and the length of this zero-stress region becomes very large (≃150%) in, for example, certain arteries.

A new application of Trichoderma asperellum as an anopheline larvicide for eco friendly management in medical science.

Microfungal applications are increasing daily in the medical science. Several species of Trichoderma are widely used in agricultural fields as biological control and plant growth promoting agents. The application of Trichoderma asperellum as an entomopathogenic fungus against the Anopheles mosquito, a vector of malaria, is a novel control approach.

Effect of cellulose nanocrystals on the performance of drug loaded in situ gelling thermo-responsive ophthalmic formulations.

Triblock poloxamer copolymer (PM) has been extensively utilized to deliver various ophthalmic pharmaceutical compounds. The aim of efficient ophthalmic drug delivery strategy is to attain the longer precorneal resident time and good bioavailability of drugs. In this pursuit, the influence of cellulose nanocrystals (CNC) on the in situ gelation behavior of PM and in vitro release of pilocarpine hydrochloride from the nanocomposites formulations was studied.

Exploring triazine and heptazine based self assembled molecular materials through first principles investigations.

Two-dimensional materials formed from the molecular self assembly of monomers through noncovalent interactions are of great importance in designing complex nanostructures with desired properties. The carbon nitride based heterocyclic systems, triazine and heptazine, are found to be promising candidates for generating various self assembled materials through (N..

Insight into the enhanced photocatalytic activity of SrTiO in the presence of a (Ni, V/Nb/Ta/Sb) pair.

Increasing applications of SrTiO3 as a photocatalyst in recent times drive the development of various strategies through doping with foreign elements to improve its efficiency under sunlight. Motivated by the recent experimental observation of increased lifetime of photogenerated charge carriers due to codoping of Ta into Ni-doped SrTiO3 (R. Niishiro et al.

Encountering epidemic effects of leaf spot disease (Alternaria brassicae) on Aloe vera by fungal biocontrol agents in agrifields-An ecofriendly approach.

Aloe vera (L.) Burm.f.

Synthesis of methylcellulose/cellulose nano-crystals nanocomposites: Material properties and study of sustained release of ketorolac tromethamine.

Non-toxic nanocomposites based bio-films obtained from methylcellulose (MC) can reduce environmental problems associated with synthetic polymers. A new facile route for the isolation of cellulose nano-crystals (CNC) from jute waste is successfully utilized here. The fabrication of CNC reinforced MC nanocomposites by film casting technique and the studies of the effect of CNC on the properties of the MC based nanocomposites have been reported.

A facile comparative approach towards utilization of waste cotton lint for the synthesis of nano-crystalline cellulose crystals along with acid recovery.

There is a need for reuse of waste cotton lint (WCL) from the blow room of yarn spinning mills. The drive to use this material for the synthesis of nanocellulose is difficult because of the several purification/pretreatment processes. Here, we developed a combined single bath purification process of WCL and utilized it for the synthesis of nano-crystalline cellulose crystals (NCs) which are valuable nanomaterials with novel properties along with acid recovery for reuse.

Optically Controlled Electron-Transfer Reaction Kinetics and Solvation Dynamics: Effect of Franck-Condon States.

Experimental results for optically controlled electron-transfer reaction kinetics (ETRK) and nonequilibrium solvation dynamics (NESD) of Coumarin 480 in DMPC vesicle show their dependence on excitation wavelength λ. However, the celebrated Marcus theory and linear-response-theory-based approaches for ETRK and NESD, respectively, predict both of the processes to be independent of λ. The above said lacuna in these theories prompted us to develop a novel theory in 1D space, where the effect of innumerable Franck-Condon states is included through λ.

DNA and protein binding, double-strand DNA cleavage and cytotoxicity of mixed ligand copper(II) complexes of the antibacterial drug nalidixic acid.

The water soluble mixed ligand complexes [Cu(nal)(diimine)(HO)](ClO) 1-4, where H(nal) is nalidixic acid and diimine is 2,2'-bipyridine (1), 1,10-phenanthroline (2), 5,6-dimethyl-1,10-phenanthroline (3), and 3,4,7,8-tetramethyl-1,10-phenanthroline (4), have been isolated. The coordination geometry around Cu(II) in 1 and that in the Density Functional Theory optimized structures of 1-4 has been assessed as square pyramidal. The trend in DNA binding constants (K) determined using absorption spectral titration (K: 1, 0.

Designing of cardanol based polyol and its curing kinetics with melamine formaldehyde resin.

Commercially used industrial baking enamels consist of alkyd or polyester resin with melamine formaldehyde. These resins are mainly derived from fossil resources. Considering growing environmental legislation regarding use of petroleum based raw materials, utilization of renewable resources to synthesize various chemistries can be the only obvious option as far as academia and industries are concerns.