Role of podoplanin, E-cadherin, Ki-67 in the dissemination of tumor cells in ovarian surface epithelial carcinoma-An immunohistochemical study.

Background/aim: To understand the biological behaviour, ovarian carcinoma should be approached as a complex tissue composed of tumor cells, ECM proteins, endothelial cells, fibroblasts, inflammatory cells and lymphatics. We aimed to investigate the role of proliferation index of the tumor cells, cell adheshion molecules and lymphangiogenesis in the dissemination of tumor in ovarian surface epithelial carcinomas using suitable antibodies.

Materials And Methods: Fifty-nine cases of ovarian carcinoma were assessed immunohistochemically to quantify the intratumoral and peritumoral LVD, podoplanin expression in stroma, E-cadherin expression and proliferation index of the tumor cells.

A Novel Subset of Triple-Negative Breast Cancers with Unique Histology and Immunohistochemical Expression.

Background & Objective: Triple-Negative Breast Carcinoma (TNBC) is characterized by an absence of estrogen receptor, progesterone receptor and HER2 neu expression, with distinct molecular, histological and clinical features, aggressive clinical course and a poor prognosis. The objective was to evaluate the expression of Cytokeratin5/6 (CK 5/6), Epidermal Growth Factor Receptor 1 (EGFR 1), E-cadherin and Androgen receptor in tissue sections of TNBC.

Methods: All modified radical mastectomy samples received negative for the three markers were subjected to further studies with CK5/6, EGFR 1, E- cadherin and Androgen receptor staining.