Validation of the Language ENvironment Analysis (LENA) Automated Speech Processing Algorithm Labels for Adult and Child Segments in a Sample of Families From India.

Purpose: The Language ENvironment Analysis (LENA) technology uses automated speech processing (ASP) algorithms to estimate counts such as total adult words and child vocalizations, which helps understand children's early language environment. This ASP has been validated in North American English and other languages in predominantly monolingual contexts but not in a multilingual context like India. Thus, the current study aims to validate the classification accuracy of the LENA algorithm specifically focusing on speaker recognition of adult segments (AdS) and child segments (ChS) in a sample of bi/multilingual families from India.

Integrating deep learning techniques for effective river water quality monitoring and management.

Effective river water quality monitoring is essential for sustainable water resource management. In this study, we established a comprehensive monitoring system along the Kaveri River, capturing real-time data on multiple critical water quality parameters. The parameters collected encompassed water contamination levels, turbidity, pH measurements, temperature, and total dissolved solids (TDS), providing a holistic view of river water quality.

Feasibility and acceptability of a caregiver-mediated early support program, delivered online, for infants at elevated familial likelihood for autism: A feasibility randomized controlled trial.

Preliminary evidence indicates potential benefit of providing caregiver-mediated intervention, prior to diagnosis, for infants at elevated familial likelihood for autism and related developmental delays including language delay (EL-A). However, delivering such interventions online and in low-resource settings like India has not been reported. This study aimed to evaluate the feasibility and acceptability of delivering a novel manualized caregiver-mediated early support program, the "LiL' STEPS," online in India, for EL-A infants.

Factors associated with delay in diagnosis of oral cancers.

Background: Oral cancer is one of the ten most common malignancies in the world and approximately 90 % of cases are OSCC. Despite the progress in available treatment modalities, the mortality of patients with OSCC has remained steadily high during the last 20 years. Survival data is strongly influenced by the timing of diagnosis: with more than 50 % of patients being diagnosed at an advanced stage, and their 5-year survival rate being less than 50 %.

GIT-Net: An Ensemble Deep Learning-Based GI Tract Classification of Endoscopic Images.

This paper presents an ensemble of pre-trained models for the accurate classification of endoscopic images associated with Gastrointestinal (GI) diseases and illnesses. In this paper, we propose a weighted average ensemble model called GIT-NET to classify GI-tract diseases. We evaluated the model on a KVASIR v2 dataset with eight classes.

Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability.

Synthetic lethality between poly(ADP-ribose) polymerase (PARP) inhibition and deficiency is exploited to treat breast and ovarian tumors. However, resistance to PARP inhibitors (PARPis) is common. To identify potential resistance mechanisms, we performed a genome-wide RNAi screen in BRCA2-deficient mouse embryonic stem cells and validation in KB2P1.

Joint IFS-ISAR-ACE Recommendations on Resuming/Opening up Assisted Reproductive Technology Services.

COVID-19 - A Global challenge on a scale not previously seen. Reproductive care is essential for the well-being of society and therefore the treatment needs to be completely re-thought and individualised. Infectivity and mortality rates are higher than previous pandemics and the disease is present in almost every country.

Noise analysis of cytosolic calcium image data.

Cellular Ca signals are often constrained to cytosolic micro- or nano-domains where stochastic openings of Ca channels cause large fluctuations in local Ca concentration (Ca 'noise'). With the advent of TIRF microscopy to image the fluorescence of Ca-sensitive probes from attoliter volumes it has become possible to directly monitor these signals, which closely track the gating of plasmalemmal and ER Ca-permeable channels. Nevertheless, it is likely that many physiologically important Ca signals are too small to resolve as discrete events in fluorescence recordings.

Non-Invasive Estimation of Hemoglobin Using a Multi-Model Stacking Regressor.

Objective: We describe a novel machine-learning based method to estimate total Hemoglobin (Hb) using photoplethysmograms (PPGs) acquired non-invasively.

Methods: In a study conducted in Karnataka, India, 1583 women (pregnant and non-pregnant) of childbearing age, with Hb values ranging between 1.6 to 14.

CellSpecks: A Software for Automated Detection and Analysis of Calcium Channels in Live Cells.

To couple the fidelity of patch-clamp recording with a more high-throughput screening capability, we pioneered a, to our knowledge, novel approach to single-channel recording that we named "optical patch clamp." By using highly sensitive fluorescent Ca indicator dyes in conjunction with total internal fluorescence microscopy techniques, we monitor Ca flux through individual Ca-permeable channels. This approach provides information about channel gating analogous to patch-clamp recording at a time resolution of ∼2 ms with the additional advantage of being massively parallel, providing simultaneous and independent recording from thousands of channels in the native environment.

C-Reactive Protein Levels and Periodontal Diseases During Pregnancy in Malaysian Women.

Purpose: To investigate the association between plasma CRP levels and periodontal disease during pregnancy.

Materials And Methods: Fifty-six pregnant women attending the Antenatal Clinic, UMMC for their first antenatal check-up consented and were recruited for this study: 28 subjects with diseased periodontium (test group) and 28 subjects with healthy periodontium (control). The test group underwent nonsurgical periodontal therapy and the control group was given oral hygiene education.

Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review.

. Several studies in the last decades have focused on finding a precise method for the diagnosis of periodontal disease in its early stages. .

Geriatric oncology: problems with under-treatment within this population.

We are currently faced with an aging population, which is rapidly growing worldwide. Two thirds of cancer occurs in the over 65-year age group. Societal conceptions from the past have created ageist stereotypes; old age is associated with frailty and the elderly are perceived to be destined for deterioration and loss of independence.

The influence of socioeconomic and demographic variables on willingness to donate cadaveric human organs in Malaysia.

The growing shortage in human organs has raised serious concerns. To address this problem, we examine in this article the association between demographic and socioeconomic factors, and respondents' willingness to donate cadaveric organs using a large survey of Malaysian adults aged 18 years and above.A convenience sampling method was used to extract information from a total of 10,350 participants from Metropolitan Kuala Lumpur over the period of April 2, 2013 to February 29, 2014.

Histologic, histomorphometric, and cone-beam computerized tomography analyses of calcium sulfate and platelet-rich plasma in socket preservation: a pilot study.

Objectives: To assess dimensional changes and histologic/histomorphometric aspects of grafted sockets using either calcium sulfate-platelet-rich plasma (CS-PRP) or CS alone in socket preservation procedure.

Study Design: Twelve subjects with single nonmolar teeth underwent atraumatic extraction. Six sockets received CS grafts and 6 sockets received CS-PRP grafts.

Effects of nonsurgical periodontal therapy on clinical response, microbiological profile, and glycemic control in Malaysian subjects with type 1 diabetes.

The association between diabetes mellitus and chronic periodontal disease has long been established. Most of the researches linking these two very common chronic diseases were based on type 2 diabetes mellitus and chronic periodontal disease. However, this study was conducted to investigate the association between type 1 diabetes and chronic periodontal disease in Malaysian subjects.

Single-molecule tracking of inositol trisphosphate receptors reveals different motilities and distributions.

Puffs are local Ca(2+) signals that arise by Ca(2+) liberation from the endoplasmic reticulum through the concerted opening of tightly clustered inositol trisphosphate receptors/channels (IP3Rs). The locations of puff sites observed by Ca(2+) imaging remain static over several minutes, whereas fluorescence recovery after photobleaching (FRAP) experiments employing overexpression of fluorescently tagged IP3Rs have shown that the majority of IP3Rs are freely motile. To address this discrepancy, we applied single-molecule imaging to locate and track type 1 IP3Rs tagged with a photoswitchable fluorescent protein and expressed in COS-7 cells.

Termination of calcium puffs and coupled closings of inositol trisphosphate receptor channels.

Calcium puffs are localized Ca(2+) signals mediated by Ca(2+) release from the endoplasmic reticulum (ER) through clusters of inositol trisphosphate receptor (IP3R) channels. The recruitment of IP3R channels during puffs depends on Ca(2+)-induced Ca(2+) release, a regenerative process that must be terminated to maintain control of cell signaling and prevent Ca(2+) cytotoxicity. Here, we studied puff termination using total internal reflection microscopy to resolve the gating of individual IP3R channels during puffs in intact SH-SY5Y neuroblastoma cells.

The probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster.

Puffs are local Ca(2+) signals that arise by Ca(2+) liberation from the endoplasmic reticulum through concerted opening of tightly clustered inositol trisphosphate receptor/channels (IP(3)R). They serve both local signaling functions and trigger global Ca(2+) waves. The numbers of functional IP(3)R within clusters differ appreciably between different puff sites, and we investigated how the probability of puff occurrence varies with cluster size.

The role of agonist-independent conformational transformation (AICT) in IP₃ cluster behavior.

Inositol 1,4,5-trisphosphate (IP(3)) receptor is a central unit in intracellular Ca(2+) signaling. Regulation of the IP₃ receptor by calcium is well characterized. High open probability values are reported for a single IP₃ receptor in nuclear patch clamp experiments.

A simple sequential-binding model for calcium puffs.

Calcium puffs describe the transient release of Ca(2+) ions into the cytosol, through small clusters of 1,4,5-inositol triphosphate (IP(3)) receptors, present on internal stores such as the endoplasmic reticulum. Statistical properties of puffs, such as puff amplitudes and durations, have been well characterized experimentally. We model calcium puffs using a simple, sequential-binding model for the IP(3) receptor in conjunction with a computationally inexpensive point-source approximation.

Comparison of quality of life in advanced laryngeal cancer patients after concurrent chemoradiotherapy vs total laryngectomy.

Objective: To compare quality of life (QOL) of patients with advanced laryngeal cancers treated by total laryngectomy with those who received concurrent chemoradiotherapy.

Study Design: This is a cross-sectional study of the patients treated in our institution who have completed one year of follow-up and were disease-free at the time of evaluation.

Subjects And Method: Forty patients treated for advanced cancer of the larynx (stage III/IV), either by concurrent chemoradiation (11) or total laryngectomy and postoperative radiation (29), have been included in this study.