Clinical entity augmented retrieval for clinical information extraction.

Large language models (LLMs) with retrieval-augmented generation (RAG) have improved information extraction over previous methods, yet their reliance on embeddings often leads to inefficient retrieval. We introduce CLinical Entity Augmented Retrieval (CLEAR), a RAG pipeline that retrieves information using entities. We compared CLEAR to embedding RAG and full-note approaches for extracting 18 variables using six LLMs across 20,000 clinical notes.

Grazing incidence nanogap resonance in the prism-gap-ferromagnet magneto-plasmonic Otto configuration.

In this Letter, we calculate the optical and magneto-optical reflectivity in a dielectric/gap/ferromagnet excited by a -polarized monochromatic optical beam through the prism (Otto configuration) as a function of the angle of incidence and the gap thickness . Besides the well-known surface plasmon polariton (SPP resonance at  ∼ ), we find a new, to the best of our knowledge, resonance with a nanometric gap  ∼ 10 nm at a large  ∼ 80°. Both resonances display pronounced resonant behavior in the transverse magneto-optical Kerr effect (T-MOKE).

Soluble Membrane Attack Complex (sMAC) as a Potential Diagnostic Biomarker Differentiating Acute Viral Encephalitis from Guillain-Barré Syndrome, a Post-infectious Autoimmune State.

Acute encephalitis syndrome (AES) presents with the onset of fever, altered sensorium and/or seizures, known to be caused by various infectious and non-infectious aetiological agents, among which viruses are the commonest. The severity of AES prompts rapid diagnosis, which is not met by time-consuming conventional diagnostic techniques. In this study, archived cerebrospinal fluid samples of laboratory-confirmed viral AES, an acute infectious condition and Guillain-Barré Syndrome (GBS), a post-infectious, autoimmune condition was assessed for soluble membrane attack complex (sMAC) using ELISA.

Anxiety in aquatics: Leveraging machine learning models to predict adult zebrafish behavior.

Accurate analysis of anxiety behaviors in animal models is pivotal for advancing neuroscience research and drug discovery. This study compares the potential of DeepLabCut, ZebraLab, and machine learning models to analyze anxiety-related behaviors in adult zebrafish. Using a dataset comprising video recordings of unstressed and pre-stressed zebrafish, we extracted features such as total inactivity duration/immobility, time spent at the bottom, time spent at the top and turn angles (large and small).

Role of intuition on problem solving style-Mediating effect of mindfulness.

The present study investigates the mediating effect of mindfulness on the role of intuition upon problem solving style among university students in India. 755 university and college students in India (Male = 310, Female = 445) completed a questionnaire that contained items of types of intuition scale (TintS) developed by Pretz et.al.

Fecal Myeloperoxidase Levels Reflect Disease Activity in Children With Crohn's Disease.

Background: Crohn's disease (CD) is a major form of inflammatory bowel disease (IBD) which has relapsing and remitting symptoms. Better ways to detect and monitor active disease are required for early diagnosis and optimal outcomes. We assessed fecal myeloperoxidase (fMPO), a neutrophil-derived enzyme that produces hypochlorous acid, as a marker of disease activity in children with CD.

Perianal Crohn's disease: Still more questions than answers.

In this editorial we comment on the article by Pacheco published in a recent issue of the . We focus specifically on the burden of illness associated with perianal fistulizing Crohn's disease (PFCD) and the diagnostic and therapeutic challenges in the management of this condition. Evolving evidence has shifted the diagnostic framework for PFCD from anatomical classification systems, to one that is more nuanced and patient-focused to drive ongoing decision making.

From darkness to discovery: evolutionary, adaptive, and translational genetic insights from cavefish.

How genotype determines phenotype is a well-explored question, but genotype-environment interactions and their heritable impact on phenotype over the course of evolution are not as thoroughly investigated. The fish Astyanax mexicanus, comprising surface and cave ecotypes, is an ideal emerging model to study the genetic basis of adaptation to new environments. This model has permitted quantitative trait locus (QTL) mapping and whole-genome comparisons to identify the genetic bases of traits such as albinism and insulin resistance and has helped in the better understanding of fundamental evolutionary mechanisms.

Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease.

Background: Identification of exposures in patients with interstitial lung diseases (ILDs) is essential for diagnosis and management and can be facilitated through the use of exposure questionnaires. However, for most ILDs, a patient-focused questionnaire is lacking. Cognitive interviewing is a methodology used to evaluate sources of understanding and misunderstanding in a questionnaire and to provide evidence of content validity.

Testing and Evaluation of Health Care Applications of Large Language Models: A Systematic Review.

Importance: Large language models (LLMs) can assist in various health care activities, but current evaluation approaches may not adequately identify the most useful application areas.

Objective: To summarize existing evaluations of LLMs in health care in terms of 5 components: (1) evaluation data type, (2) health care task, (3) natural language processing (NLP) and natural language understanding (NLU) tasks, (4) dimension of evaluation, and (5) medical specialty.

Data Sources: A systematic search of PubMed and Web of Science was performed for studies published between January 1, 2022, and February 19, 2024.

Impact of pre-acidification on the functionality and insoluble calcium levels of low-moisture part-skim mozzarella made from high-casein milk.

The use of low-concentration-factor ultrafiltered (LCF-UF) milk for cheesemaking has become popular in recent years. Research on using LCF-UF milk to make low-moisture part-skim (LMPS) mozzarella manufacture is limited due to concerns about the negative effect of the higher CN content on functional properties, such as melt and stretch. Pre-acidification (PA; reflects acid added to milk before the addition of the starter culture) has been used in low- and nonfat mozzarella cheeses to lower calcium levels and improve their texture and melting properties.

A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms.

The repeated evolution of similar phenotypes in independent lineages often occurs in response to similar environmental pressures, through similar or different molecular pathways. Recently, a repeatedly occurring mutation R263Q in a conserved domain of the protein Cryptochrome-1 (CRY1) was reported in multiple species inhabiting subterranean environments. Cryptochromes regulate circadian rhythms, and glucose and lipid metabolism.

Hyperpolarized Xe MRI and spectroscopy of gas exchange abnormalities in chronic hypersensitivity pneumonitis.

Purpose: To evaluate 3D gas-exchange functional imaging characteristics using Xe MRI in a group of study participants with chronic hypersensitivity pneumonitis (CHP) as compared with healthy control participants.

Methods: In this prospective study, 11 participants with clinical and CT findings of CHP (4M 7F, mean age 67 ± 6.1 years) as well as 41 healthy subjects (25M 16F, mean age 44 ± 18 years) were enrolled between 2017 and 2022 and underwent Xe MRI.

Design and baseline characteristics of the ILD-PRO registry in patients with progressive pulmonary fibrosis.

Background: To assess the characteristics of patients enrolled in the ILD-PRO Registry.

Methods: The ILD-PRO Registry is a multicentre US registry of patients with progressive pulmonary fibrosis. This registry is enrolling patients with an interstitial lung disease (ILD) other than idiopathic pulmonary fibrosis who have reticular abnormality and traction bronchiectasis on HRCT, and who meet criteria for ILD progression within the prior 24 months.

Deep learning dives: Predicting anxiety in zebrafish through novel tank assay analysis.

Behavior is fundamental to neuroscience research, providing insights into the mechanisms underlying thoughts, actions and responses. Various model organisms, including mice, flies, and fish, are employed to understand these mechanisms. Zebrafish, in particular, serve as a valuable model for studying anxiety-like behavior, typically measured through the novel tank diving (NTD) assay.

An open-source tool for automated human-level circling behavior detection.

Quantitatively relating behavior to underlying biology is crucial in life science. Although progress in keypoint tracking tools has reduced barriers to recording postural data, identifying specific behaviors from this data remains challenging. Manual behavior coding is labor-intensive and inconsistent, while automatic methods struggle to explicitly define complex behaviors, even when they seem obvious to the human eye.

Propagation of sharp wave-ripple activity in the mouse hippocampal CA3 subfield in vitro.

Sharp wave-ripple complexes (SPW-Rs) are spontaneous oscillatory events that characterize hippocampal activity during resting periods and slow-wave sleep. SPW-Rs are related to memory consolidation - the process during which newly acquired memories are transformed into long-lasting memory traces. To test the involvement of SPW-Rs in this process, it is crucial to understand how SPW-Rs originate and propagate throughout the hippocampus.

An App Platform-Facilitated Collaborative Palliative Care Intervention for Outpatients With Interstitial Lung Disease: A Pilot Randomized Trial.

Outpatients with interstitial lung disease often experience serious symptoms, yet infrequently receive palliative care. To determine the feasibility and clinical impact of a mobile application (PCplanner) in an outpatient setting. We conducted a pilot randomized controlled trial among adults with interstitial lung disease in a single-center academic clinic.