Photoredox cross-dehydrogenative C(sp)-C(sp) coupling of heteroarenes with secondary amines through 1,5-HAT.

The functionalization of α-C(sp)-H bonds in amines has become a focal point of contemporary research. Here, we report a new approach utilizing photocatalysis α-C(sp)-H bond functionalization in alicyclic and aliphatic secondary amines facilitated by intramolecular 1,5-hydrogen atom transfer (HAT). This finding unlocks a sustainable method for rapidly constructing complex heterocyclics cross-dehydrogenative C-C coupling of protected amines and nitrogen-containing heterocycles.