Aminoacyl-tRNA synthetase - a molecular multitasker.

Aminoacyl-tRNA synthetases (AaRSs) are valuable "housekeeping" enzymes that ensure the accurate transmission of genetic information in living cells, where they aminoacylated tRNA molecules with their cognate amino acid and provide substrates for protein biosynthesis. In addition to their translational or canonical function, they contribute to nontranslational/moonlighting functions, which are mediated by the presence of other domains on the proteins. This was supported by several reports which claim that AaRS has a significant role in gene transcription, apoptosis, translation, and RNA splicing regulation.

A multimodal facial cues based engagement detection system in e-learning context using deep learning approach.

Due to the COVID-19 crisis, the education sector has been shifted to a virtual environment. Monitoring the engagement level and providing regular feedback during e-classes is one of the major concerns, as this facility lacks in the e-learning environment due to no physical observation of the teacher. According to present study, an engagement detection system to ensure that the students get immediate feedback during e-Learning.

Facial emotion recognition based real-time learner engagement detection system in online learning context using deep learning models.

The dramatic impact of the COVID-19 pandemic has resulted in the closure of physical classrooms and teaching methods being shifted to the online medium.To make the online learning environment more interactive, just like traditional offline classrooms, it is essential to ensure the proper engagement of students during online learning sessions.This paper proposes a deep learning-based approach using facial emotions to detect the real-time engagement of online learners.

Molecular Switch between Structural Compaction and Thermodynamic Stability by the Xxx-Pro Interface in Transmembrane β-Barrels.

Transmembrane β-barrel scaffolds found in outer membrane proteins are formed and stabilized by a defined pattern of interstrand intraprotein H-bonds, in hydrophobic lipid bilayers. Introducing the conformationally constrained proline in β-barrels can cause significant destabilization of these structural regions that require H-bonding, with proline additionally acting as a secondary structure breaker. Membrane protein β-barrels are therefore expected to show poor tolerance to the presence of a transmembrane proline.