Publications by authors named "Svobodova Helena"

Background: Alzheimer's disease (AD) is the most common neurodegenerative disease and type 2 diabetes (T2D) plays an important role in conferring the risk for AD. Although AD and T2D share common features, the common molecular mechanisms underlying these two diseases remain elusive.

Methods: Mice with different AD- and/or tauopathy-linked genetic backgrounds (APPswe/PS1dE9, Tau P301L and APPswe/PS1dE9/Tau P301L) were fed for 6 months with standard diet or typical Western diet (TWD).

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Modern Holter devices are very trendy tools used in medicine, research, or sport. They monitor a variety of human physiological or pathophysiological signals. Nowadays, Holter devices have been developing very fast.

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The paper presents the application of natural materials, especially wood, which are relevant for human well-being in built environments of health, social, and day care facilities. These properties were tested by a complex methodology in a case study in the wooden waiting room at National Oncology Institute in Bratislava. In this space, experimental tests of physiological responses were further executed on 50 volunteers moving in the waiting room for 20 min.

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Article Synopsis
  • The study aimed to examine how certain genetic variants and their interactions influence HDL-c (high-density lipoprotein cholesterol) plasma levels in individuals with high triglyceride and LDL-c levels.
  • A total of 743 participants (340 men and 403 women) were analyzed, focusing on five specific genetic sites and their association with HDL-c levels using linear regression models.
  • The findings revealed that the CETP promoter variant significantly impacted HDL-c levels, while interactions between APOA1 genotype and menopause, as well as ABCA1 and APOE isoforms, also played important roles in affecting HDL-c concentrations.
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