The prognostic value of amplitude-integrated electroencephalography in neonates with hypoxic-ischemic encephalopathy.

Background/aim: Diagnosis of perinatal hypoxic-ischemic encephalopathy (HIE) and early prediction neurological outcome is important and difficult. The aim of this study was to determine the prognostic value of amplitude-integrated electroencephalography (aEEG) for abnormal neurodevelopment outcome in a neonate with HIE.

Methods: A total of 90 neonates > 32 gestational age (GA) with HIE were enrolled prospectively.

The role of oxidative stress in perinatal hypoxic-ischemic brain injury.

Introduction: The pathogenesis of perinatal hypoxic-ischemic brain damage is highly complex.

Objective: The aim of this study was to assess the role of oxidative stress in hypoxic-ischemic brain injury and subsequent abnormal neurological outcome in infants with perinatal hypoxic-ischemic encephalopathy (HIE). We estimated perinatal oxidative brain damage measuring activity of glutathione peroxidase (GPX) in cerebrospinal fluid (CSF) as an indirect biomarker of free radical production during cerebral hypoxia-ischemia in correlation with the level of intracellular enzyme neuron specific enolase (NSE) in CSF as a biomarker of extend of brain injury.

[Predictive value of color Doppler neuro-sonography for the development of neurological sequels in newborn infants with hypoxic ischemic encephalopathy].

Background/aim: The use of color Doppler neurosonography (cD-US) allows simultaneous examination of parenchymal and vascular cerebral structures. Evaluation of cerebral blood flow velocities (CBFV) and vascular resistance are important in assessment of cerebral circulation in neonates with hypoxic ischemic encephalopathy (HIE). The aim of this study was to evaluate the predictive value of cD-US for abnormal neurodevelopmental outcome in the neonates with HIE.

New insights into the pathogenesis of perinatal hypoxic-ischemic brain injury.

Background: Pathogenesis of perinatal hypoxic-ischemic brain injury (HIE) is complex. In this study, we examined the role of neuroinflammation, oxidative stress and growth factors in perinatal hypoxic-ischemic brain damage.

Methods: Ninety neonates (>32 weeks' gestation) with perinatal HIE were enrolled prospectively.

[Normal values of cerebral blood flow velocities in neonates].

Introduction: There was used color Doppler ultrasonography (cD-USI), allowing simultaneous examination of parenchymal and vascular cerebral structures. The evaluation of blood flow velocities in cerebral arteries is important in the assessment of cerebral circulation in hypoxic-ischaemic and haemorrhagic brain damage in neonates.

Objective: The aim of this study was to estimate normal values of cerebral blood flow velocities (CBFV) and Doppler indices--pulsatility index (PI) and resistance index (RI)--in the anterior cerebral artery (ACA) during the first days of life in infants.