Novel Hybrid Compound 4-[(E)-2-phenylethenesulfonamido]-N-hydroxybutanamide with Antimetastatic and Cytotoxic Action: Synthesis and Anticancer Screening.

Background: One of the most promising strategies to develop multi-targeted anticancer therapeutics is to introduce to the structure of a potential drug two or more pharmacophores (functional groups or structural fragments), which have antiproliferative, proapoptotic or antimetastatic properties acting via different mechanisms.

Objective: To design, synthesize and perform screening of a novel hybrid anticancer compound.

Method: A novel hybrid compound 4-[(E)-2-phenylethenesulfonamido]-N-hydroxybutanamide, combining butanehydroxamate and styrenesulfonamide moieties, was designed, synthesized and investigated as a potent antimetastatic and antiproliferative agent.

Synthesis and crystal structure of -(4-chloro-phen-yl)-5,7-dimethyl-1,2,4-triazolo[1,5-]pyrimidin-2-amine.

The title compound, CHClN, was synthesized by the cyclization of 1-(4,6-di-methyl-pyrimidin-2-yl)-4-phenyl-thio-semicarbazide in the presence of Ni(NO). The mol-ecular structure of the compound is essentially planar. In the crystal, mol-ecules form dimers pairs of N-H⋯N hydrogen bonds between the H atom of the exocyclic amino group and the N atom at the 4-position of the triazole ring.

Crystal structure of di-chlorido-{4-[(E)-(meth-oxy-imino-κN)meth-yl]-1,3-thia-zol-2-amine-κN (3)}palladium(II).

In the title compound, [PdCl2(C5H7N3OS)], the Pd(II) atom adopts a distorted square-planar coordination sphere defined by two N atoms of the bidentate ligand and two Cl atoms. The mean deviation from the coordination plane is 0.029 Å.

[1-(2-Oxidobenzyl-idene)-4-phenyl-thio-semicarbazidato-κO,N,S](pyridine-κN)copper(II).

In the structure of the title compound, [Cu(C(14)H(11)N(3)OS)(C(5)H(5)N)], the Cu(II) atom exhibits a slightly distorted square-planar CuN(2)OS coordination polyhedron consisting of a phenyl O, an azomethine N and a thio-amide S atom from the tridentate thio-semicarbazonate dianion, and the N atom of a pyridine mol-ecule. The thio-semicarbazonate ligand exists in the thiol tautomeric form as an E isomer. Rotational disorder of the pyridine and phenyl rings in a 1:1 ratio of the respective components is observed.

cis-(Pyridin-2-ylcarbonimidodithio-ato-κS,S')bis-(triphenyl-phosphane-κP)palladium(II).

The title compound, [Pd(C(6)H(4)N(2)S(2))(C(18)H(15)P)(2)], was obtained as a minor product from the reaction of trans-PdCl(2)(PPh(3))(2) with piperazine-1,4-dicarbothioic acid bis-(pyridin-2-yl)amide. The Pd(II) atom displays a slightly distorted square-planar PdP(2)S(2) geometry with a bidentately coordinated pyridin-2-ylcarbonimidodithio-ate ligand and two triphenyl-phosphine mol-ecules, coordinated in cis positions. The crystal structure features weak π-π [centroid-centroid distance =3.

Poly[[μ(2)-(1Z,N'E)-2-(1,3-benzothia-zol-2-ylsulfan-yl)-N'-(2-oxidobenzyl-idene-κO:O)acetohydrazidato-κO,N'](pyridine-κN)copper(II)].

In the title compound, [Cu(C(16)H(11)N(3)O(2)S(2))(C(5)H(5)N)](n), the Cu(II) atom displays a square-pyramidal CuN(2)O(3) coordination geometry with strong elongation in the vertex direction. The hydrazone mol-ecule is coordinated to the Cu(II) atom in a tridentate manner in the enolic form, creating five- and six-membered chelate metallarings. The pyridine mol-ecule completes the square-planar base of the copper coordination environment.

trans-Dichloridobis(4-methoxy-aniline-κN)palladium(II).

In the title compound, [PdCl(2)(C(7)H(9)NO)(2)], the Pd atom is situated on a crystallographic centre of inversion. The coordination environment of the Pd atom shows a slightly distorted square-planar geometry. The crystal structure exhibits weak inter-molecular Pd⋯Cl inter-actions, with Pd⋯Cl distances of 3.

cis-Bis[1-allyl-3-(2-pyrid-yl-κN)thio-ureato-κS]palladium(II).

Yellow plate-like shaped crystals of the title compound, [Pd(C(9)H(10)N(3)S)(2)], were obtained by ligand-exchange reaction between palladium(II) acetyl-acetonate and the corresponding organic reagent at room temperature. The Pd(II) atom shows a slightly distorted square-planar coordination geometry consisting of two ligand mol-ecules in a cis conformation that bind in their thio-lic tautomeric form. Weak inter-molecular Pd⋯H inter-actions with Pd-H distances of 3.