Ultrastructural features of herpesvirus-induced aortic intima damage in mice fed the high-fat diet.

Objective: The aim: To study the effect of a high-fat diet (HFD) on the structural changes in the aortic intima in intact and HSV-1-infected mice using Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM).

Patients And Methods: Materials and methods: In experiments Balb/c mice were infected with the HVS-1 and fed high-fat diet and 12 weeks later aortic ultrastructure was examined by SEM and TEM methods. The animals were subdivided into four experimental groups: 1st group - HSV-1-infected animals; 2nd - animals consuming high-fat diet (HFD); 3rd - infected animals that were subsequently consuming a high-fat diet (HSV / HFD); 4th - animals consuming a high-fat diet that were subsequently infected with HSV-1 (HFD / HSV) (n = 6); and control group - intact animals.