Publications by authors named "Svitlana Fomina"
Article Synopsis
- Cancer can lead to serious kidney issues in children requiring kidney replacement therapy (KRT), with a study identifying 287 pediatric KRT patients who had a history of cancer.
- The study showed that those whose cancer caused KRT had a longer wait for kidney transplantation compared to matched controls, with a median time of 2.4 years for cancer patients versus shorter times for controls.
- While childhood cancer survivors experienced increased mortality rates while on KRT (16% for group 1 and 23% for group 2) compared to controls, their long-term survival rates after kidney transplantation were similar to non-cancer patients.
Background: The aim of the current PodoNet registry analysis was to evaluate the outcome of steroid-resistant nephrotic syndrome (SRNS) in children who were not treated with intensified immunosuppression (IIS), focusing on the potential for spontaneous remission and the role of angiotensin blockade on proteinuria reduction.
Methods: Ninety-five pediatric patients who did not receive any IIS were identified in the PodoNet Registry. Competing risk analyses were performed on 67 patients with nephrotic-range proteinuria at disease onset to explore the cumulative rates of complete or partial remission or progression to kidney failure, stratified by underlying etiology (genetic vs.
Article Synopsis
- Primary Coenzyme Q10 (CoQ) deficiency is an ultra-rare genetic disorder that often results in nephrotic syndrome and is linked to mutations in specific genes.
- A global study of 116 patients showed that oral CoQ supplementation can lead to a significant reduction in proteinuria (by 88% at 12 months) and better preservation of kidney function over time.
- The findings suggest that all patients with primary CoQ deficiency should receive early and long-term CoQ supplementation to slow kidney disease progression and protect other organs from damage, with few mild side effects reported.
Article Synopsis
- The study examines the timing of dialysis initiation in children with end-stage kidney disease (ESKD) to understand its impact on clinical outcomes, focusing on a cohort of 2,963 children from 21 European countries.
- There are two groups analyzed based on estimated glomerular filtration rate (eGFR) at the start of dialysis: early starters (eGFR ≥8 mL/min/1.73 m²) and late starters (eGFR <8 mL/min/1.73 m²), with no significant differences found in survival or access to transplantation between the two.
- The results indicate that starting dialysis early does not provide significant clinical benefits; however, attention should be given to cardiovascular risk factors like hypertension when