Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin.

Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsulation of hydrophobic drugs, delivery of hydrophilic compounds is typically performed via covalent attachment, which often requires chemical modification of the drug and limits the release kinetics. In this paper, we report synthesis of biphilic copolymers of various compositions capable of self-assembly in water with the formation of nanoparticles and suitable for ionic binding of the common anticancer drug doxorubicin.

[The disorder of cerebral circulation in patients of able-bodied age].

The study was organized to evaluate influence of risk factors on hospital mortality in patients with acute stroke because incidence of stroke in patients of able-bodied age is increasing. All cases of in-patient care of patients of able-bodied age with acute stroke (n=4118) in the Tyumen Oblast clinical hospital № 2 during 2010-2018 were analyzed. The study was based on sampling data from hospital medical records.

Repeat testing is essential when estimating chronic kidney disease prevalence and associated cardiovascular risk.

Background: Investigations into chronic kidney disease (CKD) and cardiovascular disease in the CKD population may be misleading as they are often based on a single test of kidney function.

Aim: To determine whether repeat testing at 3 months to confirm a diagnosis of CKD impacts on the estimated prevalence of CKD and the estimated 10-year general cardiovascular risk of the CKD population.

Design And Methods: Blood and urine samples from presumed healthy volunteers were analysed for evidence of CKD on recruitment and again 3 months later.

[Continuous professional education of physicians in childhood and adolescence tuberculosis].

The current approaches to training pediatric phthisiatricians (phthisiopediatricians) are described. In the authors' opinion, completion of a clinical residency in not only phthisiology, but also in pediatrics is optimal to this group of specialists. The training programs for pediatric phthisiatricians differ in relation to the basic specialty: a phthisiatrician or a local phthisiatrician.

[The use of immunomodulator likopid in the combined treatment pulmonary tuberculosis].

Licopid is a synthetic analogue of a cell wall component of all bacteria. The monocytic macrophageal system is the main target of licopid's action. Addition of the immunomodulator to combined therapy for patients with pulmonary tuberculosis in order to enhance phagocytic activity exerted a marked clinical effect appeared as ceased bacterial isolation in 80% of the patients, a fall in the amount of purulent sputum, no symptoms of intoxication following 2-3 weeks, accelerated resolution of infiltrative changes.

[Epidemiology of tuberculosis in Moscow].

Tuberculous infection is no longer controllable in Moscow. Tuberculosis ranks first in the structure of morbidity caused by monoinfections. The prevalence of tuberculosis is increasing both among adults and children.

[Study of immunoglobulin E in sera and bronchoalveolar fluid of patients with pulmonary tuberculosis].

A highly sensitive sandwich-variety of EIA was used to measure the content of IgE in 144 sera and 59 samples of the bronchoalveolar fluid (BAF) of patients with pulmonary tuberculosis. As compared to normal persons, the content of serum IgE in the patients was significantly increased; the content of IgE in tuberculosis patients appeared as high as that in patients suffering from atopic allergy (pollenosis, bronchial asthma). The highest content of IgE was detected in patients with disseminated pulmonary tuberculosis, in the active disease phase, including those with bacterial isolation.

[Diagnostic significance of determining specific antibodies of various isotypes in patients with pulmonary tuberculosis].

The levels of antimycobacterial antibodies of three isotypes: IgG, IgA and IgM were determined in serum of 153 patients with pulmonary tuberculosis and 136 healthy donors by the solid phase enzyme immunoassay with the sonicate as the antigen. A significant and highly reliable increase in the average levels of the antimycobacterial antibodies of the IgG, IgA and IgM classes in the serum of the patients was detected as compared to the healthy persons. A significant increase (probability of 97.

[Clinical x-ray characteristics of recurrent tuberculosis of the bronchopulmonary system in patients with chronic respiratory diseases].

X-ray and clinical features of tuberculosis combined with lingering pneumonia were studied in 110 patients of the 7th group of dispensary registration suffering from chronic diseases of the respiratory organs. Tuberculosis recurrences in this group of patients had a torpid course, specific changes were slowly reversed, noticeable fibrosis was formed on their site. Thorough x-ray tomographic investigation not only of the pneumonia zone but also of the zone of posttubercular changes was conducted at the onset and end of pneumonia therapy to exclude tuberculosis reactivation.

[Eosinophilic exudative pleurisy as a manifestation of drug allergy].

The paper is concerned with a study in which eosinophilic exudative pleuritis was the first sign of drug allergy (penicillin, streptomycin, claphoran), also manifesting itself in fever, hemorrhagic eruption, eosinophilia in the blood. Fast recovery was achieved after discontinuation of antibacterial therapy and prescription of prednisolone. The problem of differential diagnosis of pleuritis in acute pneumonia is discussed.