Nitrogen-Doped Diamond-like Coatings for Long-Term Enhanced Cell Adhesion on Electrospun Poly(ε-caprolactone) Scaffold Surfaces.

Electrospun poly(ε-caprolactone) (PCL)-based scaffolds are widely used in tissue engineering. However, low cell adhesion remains the key drawback of PCL scaffolds. It is well known that nitrogen-doped diamond-like carbon (N-DLC) coatings deposited on the surface of various implants are able to enhance their biocompatibility and functional properties.

"Functional upcycling" of polymer waste towards the design of new materials.

Diversification of polymer waste recycling is one of the solutions to improve the current environmental scenario. Upcycling is a promising strategy for converting polymer waste into molecular intermediates and high-value products. Although the catalytic transformations into small molecules have been actively discussed, the methods and characteristics of upcycling into new materials have not yet been addressed.

Pulsed Vacuum Arc Deposition of Nitrogen-Doped Diamond-like Coatings for Long-Term Hydrophilicity of Electrospun Poly(ε-caprolactone) Scaffolds.

The surface hydrophobicity of poly(ε-caprolactone) electrospun scaffolds prevents their interactions with cells and tissue integration. Although plasma treatment of scaffolds enhances their hydrophilicity, this effect is temporary, and the hydrophobicity of the scaffolds is restored in about 30 days. In this communication, we report a method for hydrophilization of poly(ε-caprolactone) electrospun scaffolds for more than 6 months.

The Effect of Sibunit Carbon Surface Modification with Diazonium Tosylate Salts of Pd and Pd-Au Catalysts on Furfural Hydrogenation.

Herein, we investigated the effect of the support modification (Sibunit carbon) with diazonium salts of Pd and Pd-Au catalysts on furfural hydrogenation under 5 bars of H and 50 °C. To this end, the surface of Sibunit (Cp) was modified with butyl (Cp-Butyl), carboxyl (Cp-COOH) and amino groups (Cp-NH) using corresponding diazonium salts. The catalysts were synthesized by the sol immobilization method.

Surface modification of carbon dots with tetraalkylammonium moieties for fine tuning their antibacterial activity.

The widespread of bacterial infections including biofilms drives the never-ending quest for new antimicrobial agents. Among the great variety of nanomaterials, carbon dots (CDs) are the most promising antibacterial material, but still require the adjustment of their surface properties for enhanced activity. In this contribution, we report a facile functionalization method of carbon dots (CDs) by tetraalkylammonium moieties using diazonium chemistry to improve their antibacterial activity against Gram-positive and Gram-negative bacteria.

[Current issues of disability and rehabilitation of elderly and senile patients with lower limb loss due to vascular pathology.].

The majority of patients with amputation defect of the lower extremities are elderly citizens with high co- and polymorbidity, the presence of several geriatric syndromes, which adversely affects the prognosis, reduces the rehabilitation potential, in some cases leads to the development of cardiovascular complications, amputation of the second limb, severe disability and high postoperative mortality. The key link in the rehabilitation process of disabled people with a lower limb stump is to provide them with a functional prosthesis. The article provides an analysis of morbidity, primary disability in the period from 2015 to 2019, gender, age and clinical characteristics of patients living in St.

Components of the G signaling cascade exhibit distinct changes in mobility and membrane domain localization upon β -adrenergic receptor activation.

The G protein signaling cascade is a key player in cell signaling. Cascade activation leads to a redistribution of its members in various cellular compartments. These changes are likely related to the "second wave" of signaling from endosomes.

Designing a Scale to Assess Dialectical Thinking: Link to ECERS-R Items.

Dialectical thinking is gaining wide circulation as part of personal and social preschool child development in modern society, which makes all the more urgent the task of designing a tool to evaluate the extent to which the educational environment in a pre-school establishment supports the development of dialectical thinking in preschoolers. To implement this task, the researchers analyzed the ECERS-R as a means for assessing the quality of preschool education and concluded that this tool fails to focus on rating the environment in terms of the development of dialectical thinking. N.

[Evaluation of the effectiveness of rehabilitation of elderly patients with metabolic syndrome, taking into account the provisions of International classification of functioning, disability and health.].

The article contains data on rehabilitation measures in elderly patients with metabolic syndrome. Individual-oriented treatment and rehabilitation programs implemented in primary health care allow to reliably reduce the severity and risk of progression of restrictions of life, increase the independence of patients The elderly, having metabolic syndrome, complicated the development of type 2 diabetes mellitus. It is proposed to assess the effectiveness of rehabilitation, taking into account the provisions of the International Classification of functioning, restrictions on life and health and by drawing up an individual geriatric profile.

[Dynamics and structure of primary disability in persons of retirement age when applying to the Bureau of Medical and Social Expertise of Saint Petersburg from 2006 to 2017.].

The article presents data on primary disability in elderly and able-bodied people and older than able-bodied (retirement) age as a result of the survey of citizens in the Bureau of Medical and Social Expertise of Saint Petersburg in the period 2006-2017. The features of the level, structure, dynamics and distribution by groups of disability in retirement age are reflected. There was a significant increase in the level of disability in 2007, with a progressive decline to 2011 and a gradual decline until 2017.

Structural basis of the interaction between the putative adhesion-involved and iron-regulated FrpD and FrpC proteins of Neisseria meningitidis.

The iron-regulated protein FrpD from Neisseria meningitidis is an outer membrane lipoprotein that interacts with very high affinity (K ~ 0.2 nM) with the N-terminal domain of FrpC, a Type I-secreted protein from the Repeat in ToXin (RTX) protein family. In the presence of Ca, FrpC undergoes Ca -dependent protein trans-splicing that includes an autocatalytic cleavage of the Asp-Pro peptide bond and formation of an Asp-Lys isopeptide bond.

Backbone resonance assignments of the outer membrane lipoprotein FrpD from Neisseria meningitidis.

The iron-regulated FrpD protein is a unique lipoprotein embedded into the outer membrane of the Gram-negative bacterium Neisseria meningitidis. The biological function of FrpD remains unknown but might consist in anchoring to the bacterial cell surface the Type I-secreted FrpC protein, which belongs to a Repeat in ToXins (RTX) protein family and binds FrpD with very high affinity (K(d) = 0.2 nM).

Crystallization and preliminary crystallographic characterization of the iron-regulated outer membrane lipoprotein FrpD from Neisseria meningitidis.

Fe-regulated protein D (FrpD) is a Neisseria meningitidis outer membrane lipoprotein that may be involved in the anchoring of the secreted repeat in toxins (RTX) protein FrpC to the outer bacterial membrane. However, the function and biological roles of the FrpD and FrpC proteins remain unknown. Native and selenomethionine-substituted variants of recombinant FrpD43-271 protein were crystallized using the sitting-drop vapour-diffusion method.

[Results of the treatment of adult acute lymphoblastic leukemia according to ALL-2005 protocol as a basis for new trials].

Aim: To analyse the results of the treatment according to ALL-2005 protocol for adult patients with acute lymphoblastic leukemia (ALL); on the basis of the summarized evidence on ALL treatment to propose principles for development of a new program of ALL treatment in 15-55-year-old patients.

Material And Methods: Five hematological centers (in Moscow, Saransk, Volgograd, Tambov, Kirov) participated in ALL-2005 protocol trial initiated in 2005. A total of 71 adult patients with ALL (age median 27 years) were treated.

[Preliminary results of a multicenter randomized study on the treatment of acute promyelocytic leukemias].

Aim: To study efficacy of maintenance therapy of patients with acute promyelocytic leukemia (APL) in the APL treatment Russian multicenter trial.

Material And Methods: The trial was made with participation of 18 hematological departments of clinics in Russia. A total of 68 APL patients entered the trial.

[The molecular cellular aspects in predicting the course of an acute myocardial infarct].

Ultra-high-frequency dielectrometry was used to determine the dielectric permeability of erythrocyte suspension cell membranes in 48 patients with acute myocardial infarction who were given agonists, antagonists, and modulators of the adenylate cyclase system. The study showed that the functional status of erythrocyte membranes changed correlating with the clinical course of the disease. Changes in this status were followed by complications of improvement.

[Neurologic and mental disorders in patients with migraine and in their children].

To specify indications for differentiated therapy, a study was made of the characteristic features of the psychopathological picture of the interictal period of migraine in 50 women aged 28 to 60 years suffering from different forms of migrainous attacks. Besides, the neuropsychic disorders were also examined in those patients' children. The first group was made up of migraine patients in whom paroxysmal psychic disorders resembling convulsion-free epileptic attacks ranked first in the clinical structure of the interictal period.

[Seizure-free paroxysms in epilepsy and migraine].

Fourty epileptic and 66 migraine patients were examined. The differences in clinical features of headache paroxysms, consciousness disorders, psycho-sensory++, viscero-autonomic++ and affective spells were determined. The elements of confused consciousness, short-lived and local autonomic responses were characteristic of seizure-free epileptic attacks.

[Mental disorders in migraine patients].

The mental state was studied in patients with different forms of migraine. Using experimental psychological, electroencephalographic, rheoencephalographic, echoencephalographic and dermatoglyphic methods patients with simple and associated migraine were examined. Characteristic mental disturbances were identified.

[Several subclinical forms of epileptic dysphoria and their ambulatory treatment].

As a result of a clinico-biochemical study covering 58 epileptic patients with dysphoric states, the authors identified 2 clinical groups with the characteristic clinical features and biochemical profile. On the basis of the data obtained, a definite tactics of the treatment for dysphoric states is proposed. Multiple modality treatment with the use of anticonvulsants, neuroleptics, antidepressants and psychostimulants is recommended.