Magnetic ordering in nitrides with the eta-carbide structure, (Ni,Co,Fe)2(Ga,Ge)Mo3N.

Compositions in the series Ni(2-x)Co(x)GeMo(3)N (0 < or = x < or = 2), Co(2)Ge(1-x)Ga(x)Mo(3)N (0 < x < or = 0.7), Co(2-x)Fe(x)GeMo(3)N (0 < or = x < or = 2), and Co(2-x)Fe(x)Ge(0.5)Ga(0.

[Cytokinin inducing and antiviral activity of cycloferon on experimental herpetic infection].

Experimental data on the protective activity and the capacity for inducing the biosynthesis of some cytokins, the low molecular inductors of cycloferon, endogenic interferon of the acridanon group, in herpetic infection are presented. The herpes infection was modelled by intraperitoneal injection of herpes simplex virus, type 1 into BALB/c mice. In the animals with normal immune status cycloferon induced the formation of serum interferon (INF) in high titers (up to 1:20,000) with the peak achieved 4-8 hours after the injection of the preparation.

[The effect of salmonella infection on the functional activity of the polymorphonuclear leukocytes].

Experiments on noninbred white mice have revealed that in the animals infected with S. moscow secondary immunodeficiency develops, which is manifested by a significant decrease in the activity of the bactericidal system of peripheral blood granular leukocytes. Simultaneously, the content of myeloperoxidase in the blood neutrophils of infected mice decreases 1.

[Prolongation of the effect of immunostimulators as means of increasing resistance to causative agents of infection].

Possible prolongation of the biological effect of some available immunostimulators such as prodigiozan, salmozan, polyribonate and thymalin by their sorption on aluminium hydrate was studied. It was shown that in comparison to the native immunostimulators the sorbed ones had a more pronounced biological action and provided a more prolonged increase in the host resistance to the causative agents of gas gangrene and typhoid fever. Using prodigiozan as an example it was demonstrated that the observed increase in the anti-infective activity of the sorbed drugs was associated with more intensive stimulation of some immunological factors involved in regulation of host nonspecific resistance.

[The effect of immunostimulants on the resistance of white mice to the causative agent of typhoid fever].

The influence of prodigiosan, salmosan, polyribonate and levamisole on the body nonspecific and specific resistance to S. typhi strain 4446 has been studied. Prodigiosan and salmosan have proved to be the most effective.

[Information value of the indices of the nonspecific resistance of the body].

A number of nonspecific resistance characteristics in mice, such as the total number of peritoneal exudate cells, the percentage and absolute number of macrophages, their cytochemical activity in the spontaneous tetrazolium test and cytochemical capacity, have been studied by comparison with the resistance of the animals to tularemia infection induced by Francisella tularensis, Gaĭskiĭ's vaccinal strain 15. Of these characteristics, the cytochemical capacity of peritoneal exudate macrophages, i.e.

[Leukocyte migration inhibition reaction--an index of the antibacterial effectiveness of stimulants of the body's nonspecific resistance].

The presence of correlation between the protective action of prodigiosane and yeast RNA and the character of reaction in the direct capillary variant of the leukocyte migration inhibition (LMI) test, made with the blood of mice immunized with tularemia vaccine, has been revealed. The possibility and expediency of using the LMI test for evaluating the effectiveness of the stimulators of the nonspecific anti-infective resistance of the body has been shown.

[Effect of immunomodulators on resistance to gas gangrene. The enhanced resistance of white mice to perfringens toxin type A as affected by prodigiozan].

Experiments on 575 noninbred white mice have revealed that the nonspecific resistance of the animals to type A C. perfringens toxin can be enhanced by the administration of Prodigiosan, a commercial immunostimulating agent. Prodigiosan, introduced in 3-4 injections (the last one made 24 hours before intoxication) has been found to enhance the resistance of the animals to the subcutaneous injection of type A C.

[Comparative evaluation of the effect of immunostimulants on the dehydrogenase activity of the mouse thymus].

Comparative biochemical estimation of the influence of yeast RNA, prodigiosan and levamisole on the activity of lactate dehydrogenase, malate dehydrogenase and glutamate dehydrogenase in the thymus of mice was carried out. It was shown that the immunostimulants induced different qualitative and quantitative changes in the activity of the enzymes. Administration of yeast RNA resulted in activation of lactate dehydrogenase, malate dehydrogenase and glutamate dehydrogenase.

[Evaluation of the functional activity of peritoneal macrophages using the tetrazolium test].

The redox activity of peritoneal macrophages has been evaluated in the modified NBT test using tetranitro blue tetrazolium. This method permits the calculation of the total amount of peritoneal macrophages and the determination of their glass adherence per cent and their cytochemical activity value. The advantages of this method over the study of the phagocytic activity by means of phage T2 is shown.