Antigen-antibody complexes in experimental infection with Trichinella spiralis and their role in the development of kidney lesions.

The kidneys of rats, experimentally infected with Trichinella spiralis were studied by means of light and fluorescent microscopy. The results obtained suggest that this is a case of a proliferative intra- and extracapillary nephritis. Highest intensity of the pathological process was noted between the 30th and 50th day of the infection.

Studies on the adhesion of protoscoleces from Echinococcus multilocularis and E. granulosus to artificial substrates and human endothelial cells in vitro.

This paper describes experiments in vitro to investigate the interaction between isolated protoscoleces from Echinococcus granulosus and E. multilocularis and human endothelial cells in monolayer culture. During a maximum coculture period of 48 h neither protoscoleces nor endothelial cells showed evidence of cytotoxicity.

Brain, liver and spleen detection of liposomes after rectal administration.

Bangham-type liposomes, undergoing freeze-thawing cycles, were detected electron microscopically in the brain, liver and spleen of experimental animals 24 h after rectal administration. This novel approach has several important advantages over intravenous, intraperitoneal and other usual means of administration of liposome drug-entrapped treatment and diagnostics for human application. The location of the liposomes in the brain after rectal administration shows that the brain-blood barrier can be overcome successfully by this method.

[Pathomorphological studies of experimental echinococcosis in sheep].

Histopathologic investigations in dynamic (from the 3rd up to the 15th month of infection) were carried out on echinococcus cysts and viscera (liver, lungs, spleen, and respective lymph nodes) of sheep with an experimental infection of Echinococcus granulosus. The echinococcus cysts differed in their development. Some of them showed normal structure, while others were in various stages of degeneration or full organization with calcification.

[Dynamics of the histological changes in the liver of lambs during experimental and spontaneous Cysticercus tenuicollis invasion].

A histologic investigation of the liver was carried out with lambs after experimental and spontaneous infection with Cysticercul tenuicolis. Varying in character was the response of the host to the parasite at the site of localization. In some cases the connective tissue component was prevailing, while in others there was predominantly a cell-inflammatory demarcation around the cysts.

Immunomorphology and pathogenesis of echinococcosis. III: Microscopic immunofluorescence studies in experimental alveolar echinococcosis.

By application of immunohistological methods in experimental alveolar echinococcosis, detailed information was obtained on the antigenic properties of each component of the echinococcus cyst. It was established that of the various layers, the capsula germinativa of the parasite cyst possesses the strongest antigenicity regardless of localization and maturity of the cysts. The dissemination of echinococcal antigens within the internal organs of the experimental animals was found to follow the general trends of other infections.