Immunological and pathological investigations in equine experimental uveitis.

Background: The pathogenic mechanism of equine recurrent uveitis (ERU) is still poorly defined and many variations between experimental animal models and spontaneous disease exist.

Objectives: The aim of our study was to investigate if Th17 cell-mediated response plays role in the pathogenesis of the used experimental model in horses and to reveal its pathological findings.

Methods: Experimental uveitis was induced in 6 healthy horses.

ABC transporters in the eyes of dogs and implications in drug therapy.

Purpose: The current study aims to quantifies the level of expression of selected adenosine triphosphate-binding cassette (ABC) efflux transporters and the major drug metabolizing enzyme CYP450 3A12 in the eyes of dogs.

Materials And Methods: The levels of expression were quantified by real-time polymerase chain reaction in the cornea, conjunctiva and retinal tissue.

Results: ABCB1 mRNA is present at high levels in all analysed tissues.