Publications by authors named "Svetlana Sirota"

Background: Neutrophil-to-lymphocyte ratio (NLR) is a simple and cost-effective marker of inflammation. This marker has been shown to predict cardiac arrhythmias, progression of valvular heart disease, congestive heart failure decompensation, acute kidney injury, and mortality in cardiovascular patients. The pathologic process of aortic stenosis includes chronic inflammation of the valve and therefore biomarkers of inflammation might offer additive prognostic value.

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Article Synopsis
  • TAVR procedures can lead to acute kidney injury, but some patients may experience improvement in kidney function post-procedure, which this study investigates.
  • The study involved 1321 patients and measured kidney function through creatinine levels over a week after the procedure, categorizing them into three groups: those who improved, those who had AKI, and those with preserved function.
  • Results showed a 5% incidence of kidney function improvement, with little clinical significance for most, while AKI was more common and linked to higher mortality rates compared to those with improved or preserved function.
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Background: Estimated glomerular filtration rate (eGFR) predicts mortality and adverse cardiovascular events in people with chronic kidney disease. The significance of eGFR within the normal range and its long-term effect on clinical adverse events is unknown. We examined the effect of normal range or mildly reduced eGFR on long-term mortality in a large prospective registry.

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