Immunologic evaluation of hepatitis B vaccine application in hospital staff.

Objectives: The aim of our study was to assess immunological changes in hospital employees vaccinated five years ago with a recombinant hepatitis B vaccine.

Materials And Methods: 148 hospital employees were examined at different time periods during 5 years following a three-dose schedule of intramuscular immunization with a recombinant DNA hepatitis B vaccine (Engerix-B).

Results: At the end of a 5-year period, 20 vaccinees (13.