Publications by authors named "Svetlana Barashkova"
Background/objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies).
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- Primary ciliary dyskinesia (PCD) is a rare genetic disorder that affects cilia movement, leading to chronic respiratory issues, infertility, and laterality defects in about half of the cases; however, genetic understanding in the Russian population is limited.
- This study analyzed 21 Russian families with PCD, using advanced techniques to confirm ciliary anomalies and discover genetic variants in several PCD-related genes, including both common mutations and novel variants likely unique to Russian individuals.
- The research identified specific mutations that affect gene splicing, with one variant (c.2052+3G>T) linked to an ancestral founder mutation in the Udmurt population, highlighting the significance of regional genetic studies in understanding PCD.
Background: The existing data demonstrate the potential role of trace elements in nasal mucociliary clearance, although the association between trace element and mineral status and ciliary function in children with chronic rhinosinusitis is insufficiently studied. Therefore, the objective of the present study is evaluation of trace element and mineral status and mucociliary function in pediatric CRS patients before and after functional endoscopic sinus surgery.
Methods: The present study involved 30 children with chronic rhinosinusitis without nasal polyps.
Objective: evaluation of mucociliary clearance and mucosal morphology using high-speed videomicroscopy, and their association with markers of disease severity in children with acute (ARS) and chronic rhinosinusitis (CRS).
Methods: A total of 67 children aged from 6 to 17 years including 15 healthy children, 20 pediatric patients with acute rhinosinusitis, and 32 cases with chronic rhinosinusitis were enrolled in the present study. SNOT20, Lund-Kennedy, and Lund-Mackay scores were also evaluated.