Pre-progression rates in Alzheimer's disease revisited.

Background: Pre-progression rates (PPR) in Alzheimer's disease (AD) have been reported to be associated with cognitive and functional decline.

Objective: The objective was to reevaluate PPRs in a prospective cohort of AD patients.

Methods: A prospective AD cohort was analyzed.

CSF prion protein concentration and cognition in patients with Alzheimer disease.

Background/objective: PrP (c) has been suggested to play a role in AD pathophysiology. CSF concentrations of PrP (c) have been shown to be reduced in AD compared with healthy controls. Furthermore, serum levels of PrP (c) have recently been reported to be associated with the cognitive status of healthy elderly subjects.