Publications by authors named "Svetlana A Shlykova"
Article Synopsis
- The study analyzed DNA hydroxymethylation and methylation in human testicular cells and sperm from azoospermic patients and sperm donors, finding that while methylation was consistent throughout spermatogenesis, hydroxymethylation varied and was mostly low in sperm samples.
- High levels of hydroxymethylcytosine were primarily found in a small population of sperm cells, indicating that variations in hydroxymethylation patterns are likely not genetically programmed but may indicate abnormalities.
- Increased levels of hydroxymethylated sperm correlated negatively with markers of good semen quality and positively with sperm DNA fragmentation, suggesting that hydroxymethylation could serve as a new indicator for assessing sperm quality in infertile couples.
It is well documented that aneuploidy rate in preimplantation embryos increases with the mother's age, and at the same time the number of oocytes diminishes. Consequently, for patients of advanced maternal age two options are available to overcome these limitations: use of oocytes from young donors, or use of own oocytes coupled with preimplantation genetic screening (PGS) for 24 chromosomes. However, it is not clear which strategy might be more effective.
View Article and Find Full Text PDFComparative efficiency study of fresh and vitrified oocytes in egg donation programs for different controlled ovarian stimulation protocols.
Gynecol Endocrinol
October 2014
The aim of this study was to compare the efficacy when using vitrified and fresh eggs depending on the applied controlled ovarian stimulation protocols in egg donation programs. Study results showed that the controlled ovarian stimulation protocol does not affect the outcome of IVF/ICSI. Vitrification provided survival and pregnancy rates similar to the fresh donor oocyte ones.
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