Publications by authors named "Svetlana A Batalshchikova"
Hsp70 is the main molecular chaperone responsible for cellular proteostasis under normal conditions and for restoring the conformation or utilization of proteins damaged by stress. Increased expression of endogenous Hsp70 or administration of exogenous Hsp70 is known to exert neuroprotective effects in models of many neurodegenerative diseases. In this study, we have investigated the effect of exogenous Hsp70 on recovery from peripheral nerve injury in a model of sciatic nerve transection in rats.
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- Peripheral nerve injuries, such as neonatal brachial plexus palsy, currently lack effective treatments, prompting research into new methods for recovery.
- This study explored the application of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) on rat models with sciatic nerve injuries, demonstrating reduced muscle atrophy and improved functional recovery.
- The positive outcomes suggest that MSCs-derived EVs promote nerve regeneration and decrease neuronal death, but further research is needed to fully understand the underlying neuroprotective mechanisms.