Blood sugar, serum insulin and serum non-esterified fatty acid levels during thiopentone anaesthesia in dogs.

The purpose of this study was to determine the effect of thiopentone anaesthesia on glucose metabolism. Blood sugar (BS), serum immunoreactive insulin (IRI) and serum non-esterified fatty acid (NEFA) concentrations were measured during the course of (1) an intravenous glucose tolerance test (IVGTT), and (2) an intravenous insulin test (ITT), in conscious and anaesthetized fasted dogs. The IVGTTs were repeated in dogs under alpha- or beta-adrenergic blockade, induced by phentolamine or propranolol.

[Effects of beta-adrenergic blocking with propranolol on the mechanisms of glucose regulation in the dog].

Propranolol (P) administration is known to cause hypoglycemia in insulin-dependent diabetic patients. The mechanisms whereby this response is produced remain controversial. Some authors postulate an inhibition in the beta-adrenergic action of catecholamines, responsible for hepatic glycogenolysis, while others indicate that these hormones are not so important in the regulation of blood sugar (BS) level.

Influence of estrogen-progesterone sequential administration on pancreas cytology. Serum insulin and metabolic adjustments in female dogs.

In bitches in anestrus, artificial endometrial sex cycles were induced. Estrus was induced by 17 beta-estradiol benzoate administration; matched untreated and vehicle-treated controls were studied. Early metadiestrus (6th day after appearance of metestrum cells in vaginal smears) was induced by the sequential administration of 17 beta-estradiol benzoate and progesterone: matched studies with only one hormone or vehicles were also carried out.

In vivo and in vitro studies on the effect of the serotoninergic system on luteinizing hormone and luteinizing hormone-releasing hormone secretion in prepubertal and peripubertal female rats.

The present investigations were designed to assess the effect of the serotoninergic system on luteinizing hormone (LH) and LH-releasing hormone (LH-RH) secretion in female rats aged 14 and 30 days. The administration of 5-hydroxytryptophan (5-HTP; 75 mg/kg i.p.

Influence of exogenous ATP on blood sugar, serum insulin and serum free fatty acids in short-term experimental hyperthyroid dogs and in euthyroid controls.

We studied the influence of ATP administration on blood sugar (BS), serum immunoreactive insulin (IRI) and serum free fatty acid (FFA) responses to glucose-induced hyperglycemia in short-term experimental hyperthyroid (STEH) dogs and in euthyroid controls. Hyperthyroidism was induced by a 10-day s.c.

On changes in pancreas cytomorphometry, serum insulin and metabolic adjustments induced by long term orchidectomy and substitutive therapy with testosterone in dogs.

Mongrel, male, fasted, unanesthetized dogs under the following alternative treatments: 1) nil, 2) orchidectomy 4 months before the study, 3) orchidectomy 10 months in advance, 4) orchidectomy like in (3) followed by i.m. propylenglycol treatment, 0.

Metabolic and histological pancreatic changes induced by ovariectomy in the female dog.

The actions of ovariectomy performed 4 months in advance on pancreas cytology and also upon the blood sugar, serum immunoreactive insulin and circulating free fatty acid changes over glucose and insulin tests, were studied in female dogs. We concluded that ovariectomy does not affect blood sugar -basally or during the tests-, glucose space and clearance rate of glucose from circulation. Conversely, the integrated insulinemic response over glucose test was highly risen (956%) by ovariectomy in such animals; the rise occurs despite they show a broadened (59%) insulin space, is slightly mediated by a reduction (132%) in insulin clearance from circulation, and appears to be chiefly mediated by a major enhancement in insulin secretion.

Metabolic and pancreatic changes caused in male dogs by testosterone chronic administration.

The pancreatic cytology and the glycemic, insulinemic and serum free fatty acid responses in dogs during hyperglycemia induced by glucose and over hypoglycemia evoked by insulin have been studied. The dogs were in the alternative following conditions: untreated, under propylenglycol treatment (vehicle controls) and under testosterone propionate plus its vehicle. Testosterone dose: 0.

Effects of short-term thyroxine treatment on pancreatic cytology and responses of blood sugar, serum insulin and serum free fatty acids to epinephrine infusion.

The influence of short-term treatment with l-thyroxine on pancreatic histology and on the responses of glycemia, insulinemia and serum free fatty acids to a continuous l-epinephrine infusion in the absence or presence of alpha- and beta-adrenergic blockade was studied in male dogs. l-Epinephrine dosage: 0.06 microgram/kg body weight/min for 55 min.

Effect of estrogens on blood sugar, serum insulin and serum free fatty acids, and pancreas cytology in female dogs.

We analyzed the changes in blood sugar (BS), serum immunoreactive insulin (IRI), circulating free fatty acids (FFA) and pancreatic cytology caused by estrogenization at low pharmacological dosage in female dogs. Vehicle-injected and untreated controls (anestrus) were studied as well. Neither mean basal BS nor basal serum IRI was modified by the treatments, while the mean basal serum FFA value was raised.

Blood sugar, serum insulin and serum free fatty acid responses to graded glucose pulses in hypothyroid dogs.

The actions of hypothyroidism on BS, serum IRI and circulating FFA profiles observed in response to single glucose pulses at three levels of stimulation (1.00, 0.66 and 0.

Blood sugar, serum insulin and serum free fatty acid responses to slow graded glucose in thyroxine-treated dogs.

The effects of short-term (10 days) thyroxine administration (100 micrograms/kg body weight/die) on the BS, serum IRI and circulating FFA responses to slow, graded glucose stimulation were studied in dogs. The experiments reported demonstrated that the mean basal BS value in thyroxine-treated dogs is higher than that found in untreated controls, and that non-parallel mean BS responses to glucose infusion were observed during the test: the higher curve was found in the thyroxine-treated group. Mean basal serum IRI was similar in both groups, and parallel insulinemic responses to hyperglycemia were observed.

Effects of chronic TSH treatment on blood sugar, serum IRI and FFA levels of thyroidectomized dogs. Glucose and insulin tolerance tests.

The effects of TSH treatment (0.1 USPU/kg body weight/die, for 3-4 days) on the blood sugar, serum IRI and circulating FFA responses to glucose and insulin were studied. Blood sugar and serum FFA levels of the dogs, in basal conditions and at any time interval during the test were slightly modified by TSH treatment.

Alterations in blood sugar, serum insulin and circulating free fatty acid responses to glucose load produced in dogs by chloralose anaesthesia.

The effects of chloralose anaesthesia on the BS, serum IRI and circulating FEA responses to glucose in dogs, in the course of glucose tolerance tests were studied. Chloralose induced a moderate glucose intolerance, and abolished both, the insulin response to hyperglycaemia in these animals and the lipolytic response at the end of the test. These effects indicate that chloralose anaesthesia is definitely improper for metabolic studied in experimental biology.

[Effects of thyroid-stimulating hormone upon the regulation of serum insulin levels and on the blood sugar and serum free fatty acid responses to insulin [author's transl]].

The effect of a chronic treatment with thyroid-stimulating hormone on the blood sugar, serum insulin and free fatty acid responses to exogenous insulin in dogs was studied comparatively. Either before or after thyroid-stimulating hormone treatment, the blood sugar levels were significantly below- and serum immunoreactive insulin above- their respective base line throughout the test. The blood sugar basal value was raised by the treatment, while the blood sugar levels at any time during the test were not affected.

Experimental hyperthyroidism in dogs. Evaluation and effects on blood sugar, serum insulin and free fatty acids during glibenclamide infusion test.

The effects of hyperthyroidism on the BS, serum IRI and FFA responses to HB 419 were studied. Hyperthyroidism, induced by l-thyroxine administration, caused an increase in body temperature, respiratory rate, BS, serum FFA and PBI basal levels. Fasting serum cholesterol was reduced, and body weight, basal metabolic and heart rates, as well as basal serum insulin level failed to be affected.

Blood sugar serum insulin and free fatty acid levels in normal dogs. Sex differences.

Sex influences on blood sugar, serum immunoreactive insulin and free fatty acid levels in normal dogs, basally and during intravenous glucose tolerance tests, were studied. Serum free fatty acid levels were the variable most affected by sex in our study. They were high in males in the post-absorptive condition, with a prompt, sharp suppressibility by combined hyperglycaemia and hyperinsulinaemia, followed by intense, subsequent rebound.