[Effort-Reward Imbalance, Ability to Work and the Desire for Career Exits: a Cross-sectional Study of Nurses].

Introduction: Since the Sars-Cov-2 pandemic, the working conditions of professional caregivers have tougher. This has lead to an increased desire to leave the profession. Since thoughts of leaving are influenced by factors such as ability to work and the relationship between effort and reward, both should be recorded and examined in relation to the desire to leave the profession.

ParB-type DNA Segregation Proteins Are CTP-Dependent Molecular Switches.

During cell division, newly replicated DNA is actively segregated to the daughter cells. In most bacteria, this process involves the DNA-binding protein ParB, which condenses the centromeric regions of sister DNA molecules into kinetochore-like structures that recruit the DNA partition ATPase ParA and the prokaroytic SMC/condensin complex. Here, we report the crystal structure of a ParB-like protein (PadC) that emerges to tightly bind the ribonucleotide CTP.