Publications by authors named "Sven-Olaf Friedrich"
Background: Tuberculosis (TB) continues to result in high morbidity and mortality in children from resource-limited settings. Diagnostic challenges, including resource-intense sputum collection methods and insensitive diagnostic tests, contribute to diagnostic delay and poor outcomes in children. We evaluated the diagnostic utility of stool Xpert MTB/RIF (Xpert) compared with bacteriologic confirmation (combination of Xpert and culture of respiratory samples).
View Article and Find Full Text PDFWe prospectively compared the culture yields of two pleural fluid volumes (5 and 100 ml) inoculated in liquid culture medium in 77 patients of whom 58 (75.3%) were diagnosed with pleural tuberculosis. The overall fluid culture yield was high (60.
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- T-cells play a key role in the destruction of pancreatic beta-cells, leading to type 1 diabetes, but their specific characteristics in this disease are still unclear.
- Recent trials have shown the need for better monitoring of autoimmune reactions, emphasizing the importance of this research.
- The study identified a new marker (CD25 and CD134) for distinguishing autoreactive T-cells in type 1 diabetes patients, suggesting potential for improved therapies targeting these immune responses.