Publications by authors named "Sven Unger"
Article Synopsis
- Scientists studied a protein called Survivin to see how it affects brain cancer cells when treated with a medicine called temozolomide (TMZ).
- They found that when Survivin was stuck in the nucleus (the cell's control center), the cells couldn't repair damage caused by TMZ, leading to cell aging instead of death.
- In contrast, when Survivin was free to move in the cell, it helped the cancer cells repair themselves and survive better after the treatment.
A dearomative electrophilic fluorination of 2-methylindoles is reported, delivering 3,3-difluoroindolines bearing an exomethylidene. The model substrate was synthesized on up to a 20 mmol scale and was purified by a practical recrystallization as a crystalline bench-stable, yet reactive solid. The olefin is amphoteric and can react both as a nucleophile and as an electrophile.
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