Wound infusion of bupivacaine following radical retropubic prostatectomy: a randomised placebo-controlled clinical study.

Context: The effectiveness of postoperative analgesia through a wound catheter is subject to considerable debate.

Objective: To test the hypothesis that local wound infusion with bupivacaine followed by continuous infusion could reduce postoperative need for opioids in patients undergoing retropubic prostatectomy.

Design: Single-centre prospective, double-blinded, placebo-controlled trial.

The effect of Ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin--a double-blind, placebo-controlled, human experimental study.

The non-competitive NMDA-antagonist, Ketamine, was infused (i.v.) in healthy volunteers to study the effect on central excitability with the presence of cutaneous hyperalgesia.

Low-dose intra-articular morphine analgesia in day case knee arthroscopy: a randomized double-blinded prospective study.

The aim of this study was to demonstrate the effect of intra-articular morphine following knee arthroscopy performed in infiltration analgesia. Fifty-two healthy patients were randomized to receive either 1 mg of morphine or placebo. The pain was assessed 2, 4, 8 and 24 h after the procedure by (1) a VAS scale and (2) the amount of acetaminophen consumed.