Publications by authors named "Sven Berres"
Article Synopsis
- - The development of the Overlapping Annotated Genomic Regions (OGRE) tool aims to simplify the process of associating genomic annotations with input regions, addressing difficulties researchers face due to scattered data and the need for programming skills.
- - OGRE automates the identification and visualization of regulatory elements linked to specified genomic areas by parsing input data and publicly available annotations, presenting results in clear tables and visual formats.
- - Benchmark tests demonstrate that OGRE performs competitively against similar tools, offering additional features and successfully supporting analyses in recent genomic studies, ultimately making it a valuable resource for both bioinformaticians and researchers.
The 14th Network of Young Researchers in Andrology (NYRA) meeting was a 2-day conference held at the University of East Anglia in Norwich, UK, organized by the NYRA. The meeting brought together researchers and experts to discuss and exchange ideas on male infertility and spermatogenesis. The meeting covered a wide range of topics related to male germline research, including the impact of mutations in the male germline on future generations, the use of innovative sequencing tools for the study of male infertility, and the intricate germline epigenome.
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- Male fertility is impacted by paternal age, leading to increased germ cell mutations and potential congenital diseases in offspring.
- A study of 198 healthy men revealed that while semen and hormone profiles remain stable over time, sperm DNA stability declines after age 60, with significant methylation changes near genes related to neuronal development.
- The findings suggest a unique pattern of ageing in male germ cells, which may contribute to reduced fertility and health issues for children of older fathers.
Background: A genetic variant within the FSHB gene can deviate FSH action on spermatogenesis. The c.-211G>T FSHB single nucleotide polymorphism impacts FSHB transcription and biosynthesis due to interference with the LHX3 transcription factor binding.
View Article and Find Full Text PDFMotivation: Gene expression profiles have been widely used to study disease states. It may be possible, however, to gather insights into human diseases by comparing gene expression profiles of healthy organs with different disease incidence or severity. We tested this hypothesis and developed an approach to identify candidate genes associated with disease development by focusing on cancer incidence since it varies greatly across human organs.
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