Physical Color Calibration of Digital Pathology Scanners for Robust Artificial Intelligence Assisted Cancer Diagnosis.

The potential of artificial intelligence (AI) in digital pathology is limited by technical inconsistencies in the production of whole slide images (WSIs). This causes degraded AI performance and poses a challenge for widespread clinical application, as fine-tuning algorithms for each site is impractical. Changes in the imaging workflow can also compromise diagnostic accuracy and patient safety.

The association between patient characteristics, psychological distress, and coping in the diagnostic phase of prostate cancer - A cross-sectional multicenter study.

Purpose: This study aims to investigate the associations between patient characteristics, psychological distress, and coping in the diagnostic phase of prostate cancer.

Methods: A cross-sectional multicentre study was conducted from 2017 to 2019. A total of 250 patients were recruited from three hospitals in western Norway.

Prostate Age Gap: An MRI Surrogate Marker of Aging for Prostate Cancer Detection.

Background: Aging is the most important risk factor for prostate cancer (PC). Imaging techniques can be useful to measure age-related changes associated with the transition to diverse pathological states. However, biomarkers of aging from prostate magnetic resonance imaging (MRI) remain to be explored.

Prostate Biopsies Can Be Omitted in Most Patients with a Positive Stockholm3 Test and Negative Prostate Magnetic Resonance Imaging.

Background: Magnetic resonance imaging (MRI) combined with the Stockholm3 test can be used to inform biopsy decision-making in patients with a suspicion of prostate cancer.

Objective: To determine the consequence of omitting biopsies in men with a positive Stockholm3 test and a negative MRI.

Design, Setting, And Participants: In a real-life setting, 438 men with a positive Stockholm3 test and a negative MRI underwent systematic biopsies from 2017 to 2020.

Algorithms for early detection of silent liver fibrosis in the primary care setting - a scoping review.

Introduction: Fatty liver disease affects almost 30% of the adult population worldwide. Most patients are asymptomatic, and there is not a linear relationship between exposure to risk factors and the risk of developing fibrosis. The combination of a very large, asymptomatic risk population where only a few percent will develop life-threatening liver disease is a growing diagnostic challenge for the health services.

Preanalytical stability of plasma biomarkers for Alzheimer's disease pathology.

Introduction: Plasma tests have demonstrated high diagnostic accuracy for identifying Alzheimer's disease pathology. To facilitate the transition to clinical utility, we assessed whether plasma storage duration and temperature affect the biomarker concentrations.

Methods: Plasma samples from 13 participants were stored at +4°C and +18°C.

Men's perception of information and psychological distress in the diagnostic phase of prostate cancer: a comparative mixed methods study.

Background: Previous studies indicate that men experience frustration and uncertainty when confronted with an elevated prostate specific antigen (PSA) test and during further diagnostics for prostate cancer. The novel Stockholm3 test is an algorithm-based test that combines plasma protein biomarkers, genetic markers and clinical variables in predicting the risk of PCa. The test was introduced in a western part of Norway as a new tool for detecting prostate cancer.

General practitioners' reflections on using PSA for diagnosis of prostate cancer. A qualitative study.

Objective: To investigate how GPs use the PSA test as a diagnostic tool in daily practice.

Design: Qualitative study using focus group interviews, the transcripts being analyzed by systemic text condensation.

Subjects: A total of 17 Norwegian GPs in three CME groups.

Post-vaccination aluminium granulomas in children.

Background: Persistent itching subcutaneous granulomas related to aluminium-containing vaccines are poorly recognised in health care. They are often associated with aluminium hypersensitivity.

Case Presentation: An intensely itching subcutaneous nodule appeared on the left thigh of a 17-month-old girl at the injection site for an aluminium adsorbed diphtheria-tetanus-pertussis-polio-HiB vaccine given at 3, 5 and 12 months.

Men's perception of information and descriptions of emotional strain in the diagnostic phase of prostate cancer-a qualitative individual interview study.

Objective: To explore men`s perception of information and their possible emotional strain in the diagnostic phase of prostate cancer.

Design, Setting, Patients: A qualitative explorative research design was employed. Data were collected from June to November 2017.

Supportive care needs of men with prostate cancer after hospital discharge: multi-stakeholder perspectives.

Purpose: This study explored the supportive care needs of men with prostate cancer (PCa) after hospital discharge based on the perceptions of multiple stakeholders.

Methods: Eight semi-structured focus groups and three individual interviews were conducted between September 2019 and January 2020, with 34 participants representing men with PCa, primary and secondary healthcare professionals, and cancer organizations in western Norway. Data was analysed using systematic text condensation.

Effects of replacing PSA with Stockholm3 for diagnosis of clinically significant prostate cancer in a healthcare system - the Stavanger experience.

Objective: To describe early experience of replacing PSA with Stockholm3 for detection of prostate cancer in primary care.

Design And Methods: Longitudinal observations, comparing outcome measures before and after the implementation of Stockholm3.

Setting: Stavanger region in Norway with about 370,000 inhabitants, 304 general practitioners (GPs) in 97 primary care clinics, and one hospital.

Risk of Hospitalization in Patients with Alzheimer's Disease and Lewy Body Dementia: Time to and Length of Stay.

Background: Patients with dementia are at high risk of being hospitalized, but there is little knowledge whether this applies to all forms of dementia.

Objective: To investigate if there are differences in hospitalization between patients with Alzheimer's disease (AD) and Lewy body dementia (LBD), and further, to compare admission rate with the general age-matched population.

Methods: Patients (age 75.

Average duration of treatment with antipsychotics among concession card holders in Australia.

Objective: To analyse average treatment duration with antipsychotics reimbursed for concession card holders under the Pharmaceutical Benefits Scheme; the proportion of initial prescribing by general practitioners, psychiatrists and other physician; and the trend in drug choice in Australia.

Method: Based on a representative 10% sample of patients receiving Pharmaceutical Benefits Scheme prescriptions since 2005, antipsychotics redeemed by concession card holders in the period from 2010 to 2013 were analysed. A 5-year baseline period was used to exclude prevalent users from incident users.

Potentially inappropriate medications and drug-drug interactions in home-dwelling people with mild dementia.

Objectives: The objectives of this study were to describe the use of psychotropic drugs among home-dwelling people with mild dementia, to identify potentially inappropriate medications (PIM) and drug-drug interactions (DDI), and to analyze potential variables associated with having PIM and DDI.

Methods: Patients (n = 251) with a first-time diagnosis of mild dementia (defined as a mini-mental state examination score >20) were included from outpatient clinics. Prevalence of psychotropic drug use, polypharmacy, and psychotropic polypharmacy were investigated.

Average duration of treatment with antidepressants among concession card holders in Australia.

Objective: To analyse the average treatment duration with antidepressants that are reimbursed for concession card holders under the Pharmaceutical Benefits Scheme in Australia.

Method: This pharmacoepidemiological study was based on a representative 10% sample of patients receiving Pharmaceutical Benefits Scheme prescriptions. Antidepressants redeemed by concession card holders in the period from 2010 to 2013 were analysed.

Prescriptions for ADHD medication, 2004-08.

Background: The use of medication for ADHD has increased significantly since the 1990 s. The objective of this study was to establish the prescription rate for such drugs in Norway, and to examine which doctors prescribe them.

Material And Method: Data relating to all ADHD medication collected in the period 2004-08 was obtained from the Norwegian Prescription Database and linked to the GP database.

Use of addictive anxiolytics and hypnotics in a national cohort of incident users in Norway.

Purpose: To examine (1) incidence rates for treatment with addictive anxiolytics and hypnotics in Norway, (2) the proportions initiated by general practitioners (GPs), psychiatrists, and other physicians, and (3) the course of the treatment among incident users during a 3.5 year follow-up period.

Method: Data on all prescriptions of anxiolytics (ATC code N05B) and hypnotics (N05C) dispensed to the general population from 1 January 2004 to 31 August 2009 were extracted from the Norwegian Prescription Database and merged with data about GPs from the Norwegian Regular General Practitioner Scheme.

Psychotropic drug use in the Norwegian general population in 2005: data from the Norwegian Prescription Database.

Purpose: To analyse psychotropic drug utilisation patterns in the general population of Norway in 2005.

Methods: Data on 4,163,045 prescriptions of psychotropic drugs dispensed at all pharmacies in Norway during 2005 were extracted from The Norwegian Prescription Database (NorPD), including antipsychotics (ATC-code N05A), anxiolytics (N05B), hypnotics (N05C) and antidepressants (N06A). This information was merged with data concerning the 3857 general practitioners (GPs) from the Norwegian Regular GP Scheme.