Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia.

Magnetic hyperthermia holds significant therapeutic potential, yet its clinical adoption faces challenges. One obstacle is the large-scale synthesis of high-quality superparamagnetic iron oxide nanoparticles (SPIONs) required for inducing hyperthermia. Robust and scalable manufacturing would ensure control over the key quality attributes of SPIONs, and facilitate clinical translation and regulatory approval.

Manipulating ultrafast magnetization dynamics of ferromagnets using the odd-even layer dependence of two-dimensional transition metal di-chalcogenides.

Two-dimensional transition metal dichalcogenides (TMDs) have drawn immense interest due to their strong spin-orbit coupling and unique layer number dependence in response to spin-valley coupling. This leads to the possibility of controlling the spin degree of freedom of the ferromagnet (FM) in thin film heterostructures and may prove to be of interest for next-generation spin-based devices. Here, we experimentally demonstrate the odd-even layer dependence of WS nanolayers by measurements of the ultrafast magnetization dynamics in WS/CoFeB thin film heterostructures by using time-resolved Kerr magnetometry.

Strong In-Plane Magnetization and Spin Polarization in (CoFe)GeTe/Graphene van der Waals Heterostructure Spin-Valve at Room Temperature.

Van der Waals (vdW) magnets are promising, because of their tunable magnetic properties with doping or alloy composition, where the strength of magnetic interactions, their symmetry, and magnetic anisotropy can be tuned according to the desired application. However, so far, most of the vdW magnet-based spintronic devices have been limited to cryogenic temperatures with magnetic anisotropies favoring out-of-plane or canted orientation of the magnetization. Here, we report beyond room-temperature lateral spin-valve devices with strong in-plane magnetization and spin polarization of the vdW ferromagnet (CoFe)GeTe (CFGT) in heterostructures with graphene.

High-Order Harmonics Generation in MoS Transition Metal Dichalcogenides: Effect of Nickel and Carbon Nanotube Dopants.

The transition metal dichalcogenides have instigated a lot of interest as harmonic generators due to their exceptional nonlinear optical properties. Here, the molybdenum disulfide (MoS) molecular structures with dopants being in a plasma state are used to demonstrate the generation of intense high-order harmonics. The MoS nanoflakes and nickel-doped MoS nanoflakes produced stronger harmonics with higher cut-offs compared with Mo bulk and MoS bulk.

Direct evidence of terahertz emission arising from anomalous Hall effect.

A detailed understanding of the different mechanisms being responsible for terahertz (THz) emission in ferromagnetic (FM) materials will aid in designing efficient THz emitters. In this report, we present direct evidence of THz emission from single layer Co[Formula: see text]Fe[Formula: see text]B[Formula: see text] (CoFeB) FM thin films. The dominant mechanism being responsible for the THz emission is the anomalous Hall effect (AHE), which is an effect of a net backflow current in the FM layer created by the spin polarized current reflected at the interfaces of the FM layer.

A Room-Temperature Spin-Valve with van der Waals Ferromagnet Fe GeTe /Graphene Heterostructure.

The discovery of van der Waals (vdW) magnets opened a new paradigm for condensed matter physics and spintronic technologies. However, the operations of active spintronic devices with vdW ferromagnets are limited to cryogenic temperatures, inhibiting their broader practical applications. Here, the robust room-temperature operation of lateral spin-valve devices using the vdW itinerant ferromagnet Fe GeTe in heterostructures with graphene is demonstrated.

Revealing the Magnetic Structure and Properties of Mn(Co,Ge).

The atomic and magnetic structures of Mn(Co,Ge) are reported herein. The system crystallizes in the space group 6/ as a superstructure of the MgZn-type structure. The system exhibits two magnetic transitions with associated magnetic structures, a ferromagnetic (FM) structure around room temperature, and an incommensurate structure at lower temperatures.

Optomagnetic biosensors: Volumetric sensing based on magnetic actuation-induced optical modulations.

In comparison to alternative nanomaterials, magnetic micron/nano-sized particles show unique advantages, e.g., easy manipulation, stable signal, and high contrast.

Self-assembly of ferria - nanocellulose composite fibres.

An environmentally benign synthesis of a magnetically responsive carboxymethylated cellulose nanofibril-based material is reported. Applied experimental conditions lead to the in-situ formation of magnetite nanoparticles with primary particle sizes of 2.0-4.

Magnetic order and disorder environments in superantiferromagnetic [Formula: see text] nanoparticles.

Magnetic nanoparticles exhibit two different local symmetry environments, one ascribed to the core and one corresponding to the nanoparticle surface. This implies the existence of a dual spin dynamics, leading to the presence of two different magnetic arrangements governed by different correlation lengths. In this work, two ensembles of [Formula: see text] nanoparticles with mean sizes of 18 nm and 13 nm have been produced to unravel the magnetic couplings established among the magnetic moments located within the core and at the nanoparticle surface.

Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms.

Superparamagnetic iron oxide nanoparticles (SPIONs) generate heat upon exposure to an alternating magnetic field (AMF), which has been studied for hyperthermia treatment and triggered drug release. This study introduces a novel application of magnetic hyperthermia to induce amorphization of a poorly aqueous soluble drug, celecoxib, in situ in tablets for oral administration. Poor aqueous solubility of many drug candidates is a major hurdle in oral drug development.

Wafer-sized WS monolayer deposition by sputtering.

We demonstrate that tungsten disulphide (WS) with thicknesses ranging from monolayer (ML) to several monolayers can be grown on SiO/Si, Si, and AlO by pulsed direct current-sputtering. The presence of high quality monolayer and multilayered WS on the substrates is confirmed by Raman spectroscopy since the peak separations between the A-E and A-2LA vibration modes exhibit a gradual increase depending on the number of layers. X-ray diffraction confirms a textured (001) growth of WS films.

Influence of nano-VC on the structural and magnetic properties of MnAlC-alloy.

Alloys of MnAlC with additions of VC nano-particles have been synthesized and their properties evaluated. The MnAlC(VC) (x = 0.25, 0.

Evolution of Griffiths phase and critical behaviour of La Pb MnO solid solutions.

Polycrystalline La Pb MnO (x = 0.3, 0.35, 0.

Evolution of Griffiths Phase and Critical Behaviour of LaPbMnOSolid Solutions.

Polycrystalline LaPbMnO(x = 0.3, 0.35, 0.

Field induced crossover in critical behaviour and direct measurement of the magnetocaloric properties of LaPrCaSrMnO.

LaPrCaSrMnO has been investigated as a potential candidate for room temperature magnetic refrigeration. Results from X-ray powder diffraction reveal an orthorhombic structure with Pnma space group. The electronic and chemical properties have been confirmed by X-ray photoelectron spectroscopy and ion-beam analysis.

Insights into the Formation of DNA-Magnetic Nanoparticle Hybrid Structures: Correlations between Morphological Characterization and Output from Magnetic Biosensor Measurements.

Understanding the binding mechanism between probe-functionalized magnetic nanoparticles (MNPs) and DNA targets or amplification products thereof is essential in the optimization of magnetic biosensors for the detection of DNA. Herein, the molecular interaction forming hybrid structures upon hybridization between DNA-functionalized magnetic nanoparticles, exhibiting Brownian relaxation, and rolling circle amplification products (DNA-coils) is investigated by the use of atomic force microscopy in a liquid environment and magnetic biosensors measuring the frequency-dependent magnetic response and the frequency-dependent modulation of light transmission. This approach reveals the qualitative and quantitative correlations between the morphological features of the hybrid structures with their magnetic response.

Large Damping-Like Spin-Orbit Torque in a 2D Conductive 1T-TaS Monolayer.

A damping-like spin-orbit torque (SOT) is a prerequisite for ultralow-power spin logic devices. Here, we report on the damping-like SOT in just one monolayer of the conducting transition-metal dichalcogenide (TMD) TaS interfaced with a NiFe (Py) ferromagnetic layer. The charge-spin conversion efficiency is found to be 0.

Revisiting Goodenough-Kanamori rules in a new series of double perovskites LaSrCaNiReO.

The magnetic ground states in highly ordered double perovskites LaSrCaNiReO (x = 0.0, 0.5, 1.

Insights into the Exfoliation Process of VO·HO Nanosheet Formation Using Real-Time V NMR.

Nanostructured hydrated vanadium oxides (VO·HO) are actively being researched for applications in energy storage, catalysis, and gas sensors. Recently, a one-step exfoliation technique for fabricating VO·HO nanosheets in aqueous media was reported; however, the underlying mechanism of exfoliation has been challenging to study. Herein, we followed the synthesis of VO·HO nanosheets from the VO and VO precursors in real time using solution- and solid-state V NMR.

Observation of Skyrmions at Room Temperature in CoFeAl Heusler Alloy Ultrathin Film Heterostructures.

Magnetic skyrmions are topological spin-textures having immense potential for energy efficient spintronic devices. Here, we report the observation of stable skyrmions in unpatterned Ta/CoFeAl(CFA)/MgO thin film heterostructures at room temperature in remnant state employing magnetic force microscopy. It is shown that these skyrmions consisting of ultrathin ferromagnetic CFA Heusler alloy result from strong interfacial Dzyaloshinskii-Moriya interaction (i-DMI) as evidenced by Brillouin light scattering measurements, in agreement with the results of micromagnetic simulations.

MicroRNA Detection through DNAzyme-Mediated Disintegration of Magnetic Nanoparticle Assemblies.

DNA-assembled nanoparticle superstructures offer numerous bioresponsive properties that can be utilized for point-of-care diagnostics. Functional DNA sequences such as deoxyribozymes (DNAzymes) provide novel bioresponsive strategies and further extend the application of DNA-assembled nanoparticle superstructures. In this work, we describe a microRNA detection biosensor that combines magnetic nanoparticle (MNP) assemblies with DNAzyme-assisted target recycling.

Ferromagnetic Resonance Biosensor for Homogeneous and Volumetric Detection of DNA.

The ability to detect and analyze the state of magnetic labels with high sensitivity is of crucial importance for developing magnetic biosensors. In this work, we demonstrate, for the first time, a ferromagnetic resonance (FMR) based homogeneous and volumetric biosensor for magnetic label detection. Two different isothermal amplification methods, i.

Structural, microstructural and magnetic evolution in cryo milled carbon doped MnAl.

The low cost, rare earth free τ-phase of MnAl has high potential to partially replace bonded NdFeB rare earth permanent magnets. However, the τ-phase is metastable and it is experimentally difficult to obtain powders suitable for the permanent magnet alignment process, which requires the fine powders to have an appropriate microstructure and high τ-phase purity. In this work, a new method to make high purity τ-phase fine powders is presented.