During the last decade antimicrobial resistant pathogens have become a major medical problem. Internationally, multiresistant enterococci have increased nosocomial morbidity and mortality. Such strains are often resistant to ampicillin, aminoglycosides, and glycopeptides such as vancomycin.
View Article and Find Full Text PDFDiagn Microbiol Infect Dis
August 1992
The 150- and 300-mg single-dose pharmacokinetics of roxithromycin were investigated in 12 healthy subjects in a crossover study. Serum concentrations were determined by high-performance liquid chromatography (HPLC) and microbiologic assay (MA). Peak serum levels as measured by HPLC were 6.
View Article and Find Full Text PDFThe clinical and bacteriological efficacy and adverse reactions of ofloxacin vs trimethoprim-sulphamethoxazole were investigated in a double-blind, randomised study in 250 female patients (125 in each group) with acute, uncomplicated lower urinary tract infections. The dosages of ofloxacin and trimethoprim-sulphamethoxazole were 100mg and 160mg + 800mg twice daily, respectively. The duration of therapy was 3 days.
View Article and Find Full Text PDFScand J Infect Dis
February 1986
88 clinical isolates of gram-negative bacilli (23 Enterobacter, 23 Klebsiella, 21 E. coli, and 21 Pseudomonas) all showed susceptibility to one or more cephalosporins and were nitrocefin test negative. When cultured overnight in the presence of 1, 10, or 100 mg/l of cefotaxime, 19 Enterobacter strains grew beta-lactamase-producing variants, 15 of them at concentrations less than or equal to 10 mg/l of cefotaxime.
View Article and Find Full Text PDFEighty patients with suspected or diagnosed bacterial infections were treated with ceftazidime. Sixty-five patients with 88 sites of infections could be assessed clinically. A cure or improvement was achieved in 61 patients (94%) with a total of 83 infection sites (94%).
View Article and Find Full Text PDFActa Pathol Microbiol Immunol Scand B
December 1982
Br J Vener Dis
October 1982
The antigonococcal activity of the quinolone derivative flumequine was evaluated. Of 246 strains examined, 240 (97.5%) strains showed minimum inhibitory concentrations (MICs) of flumequine of less than or equal to 0.
View Article and Find Full Text PDFScand J Infect Dis Suppl
February 1982
Pharmacokinetic properties and clinical efficiency of azlocillin were investigated in three patients with terminal renal failure both during and without haemodialysis. All patients were treated for urinary tract infections with azlocillin 2 g three times daily for a period of ten days. Mean serum half-lives off dialysis were 251 min and on dialysis 202 min.
View Article and Find Full Text PDFScand J Infect Dis
March 1981
12 patients with severe renal insufficiency were treated for urinary tract infection with 400 mg of mecillinam intravenously every 6 h. High serum concentrations of mecillinam were found 6 h after the first morning dose on day 2 and day 5 of the treatment period (mean values 11.4 and 14.
View Article and Find Full Text PDFActa Pathol Microbiol Scand B
December 1979
A "chocolate" agar medium (CA-NCV) containing nystatin, colistin and vancomycin, was compared with the MNYC medium which contain lincomycin, colistin, amphotericin and trimethoprim. A total of 277 clinical specimens were cultured for gonococci, and 120 of these showed positive cultures on either or both of the media. The MNYC medium detected 96.
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