Publications by authors named "Suzin M Webb"
Article Synopsis
- Feline chronic gingivostomatitis (FCGS) is a painful oral condition in cats, marked by inflammation and ulcers in the mouth, but the exact causes are still unclear.
- Researchers conducted RNA sequencing on tissue samples from affected and healthy cats to find genes and pathways involved in FCGS for potential treatment options.
- The study found that certain immune-related genes and pathways, particularly influenced by IL6, are overrepresented in affected tissues, suggesting new avenues for clinical interventions.
Article Synopsis
- Feline chronic gingivostomatitis (FCGS) is a painful disease in cats that causes sores and inflammation in their mouths.
- Scientists studied the genes in affected cats' tissues to find out what might be causing the disease and how to help.
- They discovered that many genes related to the immune system and inflammation were involved, which could help them create better treatments for the disease in the future.
Article Synopsis
- Oral squamous cell carcinoma (OSCC) is a highly aggressive form of oral cancer in dogs with a 0% one-year survival rate when untreated.
- The study indicates that a significant percentage (up to 85.7%) of canine papillary OSCC tumors have a specific BRAF mutation, supporting its role in tumor development.
- Findings from the research could lead to improved diagnostic methods and targeted therapies for this cancer type, enhancing veterinary care for affected dogs.
Rationale: A common polymorphism (5HTTLPR) within the promoter region of the serotonin transporter gene (LSC6A4) has been shown to influence response time as well as overall response to selective serotonin reuptake inhibitors (SSRIs) in subjects with major depressive disorder. We hypothesized that a similar effect in response time to sertraline would be observed and that no effect on response time would be seen in a placebo arm.
Objectives: We tested the hypothesis that subjects homozygous for the long allele at the 5HTTLPR polymorphism would respond more rapidly to sertraline than subjects carrying one or two copies of the short allele.